STK39

Serine threonine kinase 39
Identifiers
Symbols	STK39 ; DCHT; PASK; SPAK
External IDs	OMIM: 607648 MGI: 1858416 HomoloGene: 22739 IUPHAR: 2224 ChEMBL: 1163108 GeneCards: STK39 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • receptor signaling protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding Cellular component • nucleus • cytoplasm • cytoskeleton • basolateral plasma membrane • apical plasma membrane Biological process • negative regulation of protein phosphorylation • protein phosphorylation • response to stress • regulation of mitotic cell cycle • regulation of blood pressure • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • intracellular signal transduction • regulation of apoptotic process • positive regulation of potassium ion transport • regulation of inflammatory response • cellular hypotonic response • negative regulation of potassium ion transmembrane transporter activity • negative regulation of potassium ion transmembrane transport • regulation of ion homeostasis • negative regulation of rubidium ion transport • negative regulation of rubidium ion transmembrane transporter activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27347	53416
Ensembl	ENSG00000198648	ENSMUSG00000027030
UniProt	Q9UEW8	Q9Z1W9
RefSeq (mRNA)	NM_013233	NM_016866
RefSeq (protein)	NP_037365	NP_058562
Location (UCSC)	Chr 2: 167.95 – 168.25 Mb	Chr 2: 68.21 – 68.47 Mb
PubMed search

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.^[1][2]

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.^[2] Some studies suggest that this gene might be linked to high blood pressure.^[3]

References

1. Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ (Oct 2000). "SPAK, a STE20/SPS1-related kinase that activates the p38 pathway". Oncogene 19 (37): 4290–7. doi:10.1038/sj.onc.1203784. PMID 10980603.
2. "Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)".
3. "Reuters: Key gene linked to high blood pressure identified". 29 December 2008.

Further reading

• Qi H, Labrie Y, Grenier J, et al. (2001). "Androgens induce expression of SPAK, an STE20/SPS1-related kinase, in LNCaP human prostate cancer cells". Mol. Cell. Endocrinol. 182 (2): 181–92. doi:10.1016/S0303-7207(01)00560-3. PMID 11514053.
• Dowd BF, Forbush B (2003). "PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)". J. Biol. Chem. 278 (30): 27347–53. doi:10.1074/jbc.M301899200. PMID 12740379.
• Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na⁺-K⁺-2Cl⁻ cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". J. Biol. Chem. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
• Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMC 1479760. PMID 16669787.
• Polek TC, Talpaz M, Spivak-Kroizman TR (2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem. Biophys. Res. Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Yan Y, Nguyen H, Dalmasso G, et al. (2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochim. Biophys. Acta 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517. PMID 17321610.