STMN3

Stathmin-like 3
Identifiers
Symbols	STMN3 ; SCLIP
External IDs	OMIM: 608362 MGI: 1277137 HomoloGene: 7528 GeneCards: STMN3 Gene
Gene ontology Molecular function • tubulin binding • protein domain specific binding Cellular component • cytoplasm • Golgi apparatus • axon • growth cone • neuron projection Biological process • microtubule depolymerization • nervous system development • regulation of microtubule polymerization or depolymerization • cytoplasmic microtubule organization • neuron projection development • negative regulation of Rac protein signal transduction • regulation of GTPase activity • regulation of cytoskeleton organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50861	20262
Ensembl	ENSG00000197457	ENSMUSG00000027581
UniProt	Q9NZ72	O70166
RefSeq (mRNA)	NM_001276310	NM_009133
RefSeq (protein)	NP_001263239	NP_033159
Location (UCSC)	Chr 20: 63.64 – 63.66 Mb	Chr 2: 181.31 – 181.31 Mb
PubMed search

Stathmin-3 is a protein that in humans is encoded by the STMN3 gene.^[1][2][3]

The protein encoded by this gene belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. It is similar to the SCG10 protein and is involved in signal transduction and regulation of microtubule dynamics.^[3]

Interactions

STMN3 has been shown to interact with TRPC5.^[4]

References

1. Ozon S, Byk T, Sobel A (Jun 1998). "SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system". J Neurochem 70 (6): 2386–96. doi:10.1046/j.1471-4159.1998.70062386.x. PMID 9603203.
2. Bai C, Connolly B, Metzker ML, Hilliard CA, Liu X, Sandig V, Soderman A, Galloway SM, Liu Q, Austin CP, Caskey CT (Mar 2000). "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster". Proc Natl Acad Sci U S A 97 (3): 1230–5. doi:10.1073/pnas.97.3.1230. PMC 15578. PMID 10655513.
3. "Entrez Gene: STMN3 stathmin-like 3".
4. Greka, Anna; Navarro Betsy; Oancea Elena; Duggan Anne; Clapham David E (Aug 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nat. Neurosci. (United States) 6 (8): 837–45. doi:10.1038/nn1092. ISSN 1097-6256. PMID 12858178.

Further reading

• Gavet O, Ozon S, Manceau V, et al. (1999). "The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network.". J. Cell. Sci. 111 (22): 3333–46. PMID 9788875.
• Charbaut E, Curmi PA, Ozon S, et al. (2001). "Stathmin family proteins display specific molecular and tubulin binding properties.". J. Biol. Chem. 276 (19): 16146–54. doi:10.1074/jbc.M010637200. PMID 11278715.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bièche I, Maucuer A, Laurendeau I, et al. (2003). "Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP.". Genomics 81 (4): 400–10. doi:10.1016/S0888-7543(03)00031-4. PMID 12676564.
• Greka A, Navarro B, Oancea E, et al. (2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.". Nat. Neurosci. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.