STRAP

Serine/threonine kinase receptor associated protein
Identifiers
Symbols	STRAP ; MAWD; PT-WD; UNRIP
External IDs	OMIM: 605986 MGI: 1329037 HomoloGene: 43881 GeneCards: STRAP Gene
Gene ontology Molecular function • receptor binding • protein binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • plasma membrane • SMN complex • SMN-Sm protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • spliceosomal snRNP assembly • transforming growth factor beta receptor signaling pathway • negative regulation of epithelial cell migration • negative regulation of epithelial to mesenchymal transition • maintenance of gastrointestinal epithelium • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of epithelial cell proliferation • negative regulation of pathway-restricted SMAD protein phosphorylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11171	20901
Ensembl	ENSG00000023734	ENSMUSG00000030224
UniProt	Q9Y3F4	Q9Z1Z2
RefSeq (mRNA)	NM_007178	NM_011499
RefSeq (protein)	NP_009109	NP_035629
Location (UCSC)	Chr 12: 15.88 – 15.9 Mb	Chr 6: 137.74 – 137.75 Mb
PubMed search

Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.^[1]

Interactions

STRAP has been shown to interact with:

• Mothers against decapentaplegic homolog 2,^[2]
• Mothers against decapentaplegic homolog 3,^[2]
• Mothers against decapentaplegic homolog 6,^[2]
• Mothers against decapentaplegic homolog 7,^[2]
• TGF beta receptor 1,^[2][3] and
• TGF beta receptor 2.^[2][3]

References

1. "Entrez Gene: STRAP serine/threonine kinase receptor associated protein".
2. Datta PK, Moses HL (May 2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling". Mol. Cell. Biol. 20 (9): 3157–67. doi:10.1128/mcb.20.9.3157-3167.2000. PMC 85610. PMID 10757800.
3. Datta PK, Chytil A, Gorska AE, Moses HL (December 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. 273 (52): 34671–4. doi:10.1074/jbc.273.52.34671. PMID 9856985.

Further reading

• Datta PK, Chytil A, Gorska AE, Moses HL (1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. 273 (52): 34671–4. doi:10.1074/jbc.273.52.34671. PMID 9856985.
• Hunt SL, Hsuan JJ, Totty N, Jackson RJ (1999). "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA". Genes Dev. 13 (4): 437–48. doi:10.1101/gad.13.4.437. PMC 316477. PMID 10049359.
• Matsuda S, Katsumata R, Okuda T, Yamamoto T, Miyazaki K, Senga T, Machida K, Thant AA, Nakatsugawa S, Hamaguchi M (2000). "Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer". Cancer Res. 60 (1): 13–7. PMID 10646843.
• Datta PK, Moses HL (2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling". Mol. Cell. Biol. 20 (9): 3157–67. doi:10.1128/MCB.20.9.3157-3167.2000. PMC 85610. PMID 10757800.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Iriyama C, Matsuda S, Katsumata R, Hamaguchi M (2001). "Cloning and sequencing of a novel human gene which encodes a putative hydroxylase". J. Hum. Genet. 46 (5): 289–92. doi:10.1007/s100380170081. PMID 11355021.
• Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
• Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL (2005). "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity". Science 307 (5715): 1603–9. doi:10.1126/science.1105718. PMID 15761148.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Carissimi C, Baccon J, Straccia M, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L (2005). "Unrip is a component of SMN complexes active in snRNP assembly". FEBS Lett. 579 (11): 2348–54. doi:10.1016/j.febslet.2005.03.034. PMID 15848170.
• Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Hum. Mol. Genet. 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Seong HA, Jung H, Choi HS, Kim KT, Ha H (2005). "Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein". J. Biol. Chem. 280 (52): 42897–908. doi:10.1074/jbc.M507539200. PMID 16251192.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". J. Biol. Chem. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
• Seong HA, Jung H, Ha H (2007). "NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling". J. Biol. Chem. 282 (16): 12075–96. doi:10.1074/jbc.M609832200. PMID 17314099.