STS-1 (gene)

Ubiquitin associated and SH3 domain containing B
PDB rendering based on 2cpw.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CPW​, 2E5K​
Identifiers
Symbols	UBASH3B ; STS-1; STS1; TULA-2; TULA2; p70
External IDs	OMIM: 609201 MGI: 1920078 HomoloGene: 13152 GeneCards: UBASH3B Gene
EC number	3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein binding Cellular component • nucleus • cytoplasm Biological process • negative regulation of protein kinase activity • peptidyl-tyrosine dephosphorylation • regulation of osteoclast differentiation • regulation of release of sequestered calcium ion into cytosol • negative regulation of platelet aggregation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84959	72828
Ensembl	ENSG00000154127	ENSMUSG00000032020
UniProt	Q8TF42	Q8BGG7
RefSeq (mRNA)	NM_032873	NM_176860
RefSeq (protein)	NP_116262	NP_789830
Location (UCSC)	Chr 11: 122.66 – 122.81 Mb	Chr 9: 41.01 – 41.16 Mb
PubMed search

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.^[1][2][3]

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.^[3]

References

1. Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
2. Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC 135669. PMID 12370296.
3. "Entrez Gene: STS-1 Cbl-interacting protein Sts-1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
• Guo F, Sigua C, Bali P, et al. (2005). "Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.". Blood 105 (3): 1246–55. doi:10.1182/blood-2004-05-2041. PMID 15388581.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination.". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130.