SUGT1

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
PDB rendering based on 1rl1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1RL1​
Identifiers
Symbols	SUGT1 ; SGT1
External IDs	OMIM: 604098 MGI: 1915205 HomoloGene: 4877 GeneCards: SUGT1 Gene
Gene ontology Molecular function • protein binding Cellular component • ubiquitin ligase complex • kinetochore • nucleus • cytoplasm • cytosol Biological process • mitotic nuclear division • regulation of protein stability • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • positive regulation by host of symbiont catalytic activity • innate immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10910	67955
Ensembl	ENSG00000165416	ENSMUSG00000022024
UniProt	Q9Y2Z0	Q9CX34
RefSeq (mRNA)	NM_001130912	NM_026474
RefSeq (protein)	NP_001124384	NP_080750
Location (UCSC)	Chr 13: 52.65 – 52.7 Mb	Chr 14: 79.59 – 79.63 Mb
PubMed search

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.^[1][2]

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.^[2]

Interactions

SUGT1 has been shown to interact with S100A6.^[3]

References

1. Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (Aug 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Mol Cell 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
2. "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
3. Nowotny, Marcin; Spiechowicz Magdalena; Jastrzebska Beata; Filipek Anna; Kitagawa Katsumi; Kuznicki Jacek (Jul 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. (United States) 278 (29): 26923–8. doi:10.1074/jbc.M211518200. ISSN 0021-9258. PMID 12746458.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Nowotny M, Spiechowicz M, Jastrzebska B, et al. (2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.". J. Biol. Chem. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
• Niikura Y, Kitagawa K (2004). "Identification of a novel splice variant: human SGT1B (SUGT1B).". DNA Seq. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID 15018354.
• Zou X, Ji C, Wang L, et al. (2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1.". DNA Seq. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID 15346769.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (2007). "SGT1 is essential for Nod1 activation.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6764–9. doi:10.1073/pnas.0610926104. PMC 1871859. PMID 17420470.
• Spiechowicz M, Zylicz A, Bieganowski P, et al. (2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6.". Biochem. Biophys. Res. Commun. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.