SULF2

Sulfatase 2
Identifiers
Symbols	SULF2 ; HSULF-2
External IDs	OMIM: 610013 MGI: 1919293 HomoloGene: 10313 GeneCards: SULF2 Gene
Gene ontology Molecular function • arylsulfatase activity • calcium ion binding • N-acetylglucosamine-6-sulfatase activity Cellular component • extracellular space • endoplasmic reticulum • Golgi stack • plasma membrane • cell surface Biological process • kidney development • chondrocyte development • glomerular filtration • positive regulation of vascular endothelial growth factor production • esophagus smooth muscle contraction • positive regulation of Wnt signaling pathway • heparan sulfate proteoglycan metabolic process • glomerular basement membrane development • glial cell-derived neurotrophic factor receptor signaling pathway • negative regulation of fibroblast growth factor receptor signaling pathway • embryonic skeletal system development • cartilage development • bone development • innervation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55959	72043
Ensembl	ENSG00000196562	ENSMUSG00000006800
UniProt	Q8IWU5	Q8CFG0
RefSeq (mRNA)	NM_001161841	NM_001252578
RefSeq (protein)	NP_001155313	NP_001239507
Location (UCSC)	Chr 20: 47.66 – 47.79 Mb	Chr 2: 166.07 – 166.16 Mb
PubMed search

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.^[1][2]

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]^[2]

References

1. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD (Dec 2002). "Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans". J Biol Chem 277 (51): 49175–85. doi:10.1074/jbc.M205131200. PMC 2779716. PMID 12368295.
2. "Entrez Gene: SULF2 sulfatase 2".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dai Y, Yang Y, MacLeod V, et al. (2006). "HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo". J. Biol. Chem. 280 (48): 40066–73. doi:10.1074/jbc.M508136200. PMID 16192265.
• Morimoto-Tomita M, Uchimura K, Bistrup A, et al. (2006). "Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer". Neoplasia 7 (11): 1001–10. doi:10.1593/neo.05496. PMC 1502017. PMID 16331886.
• Uchimura K, Morimoto-Tomita M, Bistrup A, et al. (2006). "HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1". BMC Biochem. 7: 2. doi:10.1186/1471-2091-7-2. PMC 1386684. PMID 16417632.