SULT1C2

Sulfotransferase family, cytosolic, 1C, member 2
PDB rendering based on 2etg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BFX​
Identifiers
Symbols	SULT1C2 ; ST1C1; ST1C2; SULT1C1; humSULTC2
External IDs	OMIM: 602385 HomoloGene: 38201 ChEMBL: 1743295 GeneCards: SULT1C2 Gene
EC number	2.8.2.-
Gene ontology Molecular function • sulfotransferase activity Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • xenobiotic metabolic process • amine metabolic process • small molecule metabolic process • 3'-phosphoadenosine 5'-phosphosulfate metabolic process • sulfation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6819	69083
Ensembl	ENSG00000198203	ENSMUSG00000023122
UniProt	O00338	Q9D939
RefSeq (mRNA)	NM_001056	NM_026935
RefSeq (protein)	NP_001047	NP_081211
Location (UCSC)	Chr 2: 108.29 – 108.31 Mb	Chr 17: 53.83 – 53.85 Mb
PubMed search

Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.^[1][2][3]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[3]

References

1. Her C, Kaur GP, Athwal RS, Weinshilboum RM (Jul 1997). "Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization". Genomics 41 (3): 467–70. doi:10.1006/geno.1997.4683. PMID 9169148.
2. Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM (Jul 2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization". Genomics 65 (2): 157–65. doi:10.1006/geno.2000.6150. PMID 10783263.
3. "Entrez Gene: SULT1C1 sulfotransferase family, cytosolic, 1C, member 1".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. PMID 9034160.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112-113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Kiehlbauch CC, Lam YF, Ringer DP (1995). "Homodimeric and heterodimeric aryl sulfotransferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene". J. Biol. Chem. 270 (32): 18941–7. doi:10.1074/jbc.270.32.18941. PMID 7642552.
• Yoshinari K, Nagata K, Shimada M, Yamazoe Y (1998). "Molecular characterization of ST1C1-related human sulfotransferase". Carcinogenesis 19 (5): 951–3. doi:10.1093/carcin/19.5.951. PMID 9635888.
• Sakakibara Y, Yanagisawa K, Katafuchi J, et al. (1999). "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene". J. Biol. Chem. 273 (51): 33929–35. doi:10.1074/jbc.273.51.33929. PMID 9852044.
• Hehonah N, Zhu X, Brix L, et al. (1999). "Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase". Int. J. Biochem. Cell Biol. 31 (8): 869–82. doi:10.1016/S1357-2725(99)00038-2. PMID 10481272.
• Li X, Clemens DL, Anderson RJ (2000). "Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*". Biochem. Pharmacol. 60 (11): 1713–6. doi:10.1016/S0006-2952(00)00475-5. PMID 11077054.
• Freimuth RR, Eckloff B, Wieben ED, Weinshilboum RM (2002). "Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies". Pharmacogenetics 11 (9): 747–56. doi:10.1097/00008571-200112000-00002. PMID 11740338.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Dombrovski L, Dong A, Bochkarev A, Plotnikov AN (2006). "Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)". Proteins 64 (4): 1091–4. doi:10.1002/prot.21048. PMID 16804942.