SUV39H2

Suppressor of variegation 3-9 homolog 2 (Drosophila)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2R3A​
Identifiers
Symbols	SUV39H2 ; KMT1B
External IDs	OMIM: 606503 MGI: 1890396 HomoloGene: 32548 IUPHAR: 2716 ChEMBL: 1795177 GeneCards: SUV39H2 Gene
EC number	2.1.1.43
Gene ontology Molecular function • transcription regulatory region sequence-specific DNA binding • protein binding • zinc ion binding • histone methyltransferase activity (H3-K9 specific) Cellular component • chromosome, centromeric region • chromatin • nucleoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • chromatin assembly or disassembly • chromatin remodeling • transcription, DNA-templated • cell cycle • cell differentiation • histone H3-K9 dimethylation • histone H3-K9 trimethylation • negative regulation of circadian rhythm • negative regulation of transcription, DNA-templated • rhythmic process • cellular response to hypoxia Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79723	64707
Ensembl	ENSG00000152455	ENSMUSG00000026646
UniProt	Q9H5I1	Q9EQQ0
RefSeq (mRNA)	NM_001193424	NM_022724
RefSeq (protein)	NP_001180353	NP_073561
Location (UCSC)	Chr 10: 14.88 – 14.9 Mb	Chr 2: 3.46 – 3.48 Mb
PubMed search

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.^[1][2]

References

1. O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.
2. "Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature 406 (6796): 593–9. doi:10.1038/35020506. PMID 10949293.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells". EMBO J. 23 (3): 605–15. doi:10.1038/sj.emboj.7600074. PMC 1271807. PMID 14765126.
• Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene 23 (30): 5242–51. doi:10.1038/sj.onc.1207660. PMID 15107829.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis 27 (11): 2217–22. doi:10.1093/carcin/bgl084. PMID 16774942.