SUZ12

SUZ12 polycomb repressive complex 2 subunit
Identifiers
Symbols	SUZ12 ; CHET9; JJAZ1
External IDs	OMIM: 606245 MGI: 1261758 HomoloGene: 32256 GeneCards: SUZ12 Gene
Gene ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • chromatin binding • RNA binding • protein binding • methylated histone binding • histone methyltransferase activity • metal ion binding Cellular component • sex chromatin • nucleus • nucleoplasm • nucleolus • ESC/E(Z) complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • positive regulation of cell proliferation • gene expression • histone methylation • histone ubiquitination • regulation of gene expression, epigenetic • negative regulation of cell differentiation • negative regulation of gene expression, epigenetic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23512	52615
Ensembl	ENSG00000178691	ENSMUSG00000017548
UniProt	Q15022	Q80U70
RefSeq (mRNA)	NM_015355	NM_001163018
RefSeq (protein)	NP_056170	NP_001156490
Location (UCSC)	Chr 17: 31.94 – 32 Mb	Chr 11: 79.99 – 80.03 Mb
PubMed search

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.^[1][2][3][4] This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.^[4]

SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.^[5]

References

1. Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
2. Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J (May 2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proc Natl Acad Sci U S A 98 (11): 6348–53. doi:10.1073/pnas.101132598. PMC 33471. PMID 11371647.
3. Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB (Dec 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction 136 (6): 777–85. doi:10.1530/REP-08-0045. PMID 18784248.
4. "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)".
5. Rinn JL, Kertesz M, Wang JK, et al. (June 2007). "Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Non-Coding RNAs". Cell 129 (7): 1311–23. doi:10.1016/j.cell.2007.05.022. PMC 2084369. PMID 17604720. Retrieved 2010-07-20.

Further reading

• Birve A, Sengupta AK, Beuchle D, et al. (2001). "Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants". Development 128 (17): 3371–9. PMID 11546753.
• Weinmann AS, Bartley SM, Zhang T, et al. (2001). "Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters". Mol. Cell. Biol. 21 (20): 6820–32. doi:10.1128/MCB.21.20.6820-6832.2001. PMC 99859. PMID 11564866.
• Cao R, Wang L, Wang H, et al. (2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science 298 (5595): 1039–43. doi:10.1126/science.1076997. PMID 12351676.
• Kuzmichev A, Nishioka K, Erdjument-Bromage H, et al. (2002). "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein". Genes Dev. 16 (22): 2893–905. doi:10.1101/gad.1035902. PMC 187479. PMID 12435631.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petek E, Jenne DE, Smolle J, et al. (2003). "Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations". J. Med. Genet. 40 (7): 520–5. doi:10.1136/jmg.40.7.520. PMC 1735521. PMID 12843325.
• Wang H, An W, Cao R, et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell 12 (2): 475–87. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
• Huang HY, Ladanyi M, Soslow RA (2004). "Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity". Am. J. Surg. Pathol. 28 (2): 224–32. doi:10.1097/00000478-200402000-00010. PMID 15043312.
• Cao R, Zhang Y (2004). "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex". Mol. Cell 15 (1): 57–67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
• Kehrer-Sawatzki H, Kluwe L, Sandig C, et al. (2004). "High Frequency of Mosaicism among Patients with Neurofibromatosis Type 1 (NF1) with Microdeletions Caused by Somatic Recombination of the JJAZ1 Gene". Am. J. Hum. Genet. 75 (3): 410–23. doi:10.1086/423624. PMC 1182020. PMID 15257518.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Pasini D, Bracken AP, Jensen MR, et al. (2004). "Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity". EMBO J. 23 (20): 4061–71. doi:10.1038/sj.emboj.7600402. PMC 524339. PMID 15385962.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cha TL, Zhou BP, Xia W, et al. (2005). "Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3". Science 310 (5746): 306–10. doi:10.1126/science.1118947. PMID 16224021.
• Lee TI, Jenner RG, Boyer LA, et al. (2006). "Control of developmental regulators by Polycomb in human embryonic stem cells". Cell 125 (2): 301–13. doi:10.1016/j.cell.2006.02.043. PMID 16630818.
• Furuno K, Masatsugu T, Sonoda M, et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro". Biochem. Biophys. Res. Commun. 345 (3): 1051–8. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Nucci MR, Harburger D, Koontz J, et al. (2007). "Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms". Am. J. Surg. Pathol. 31 (1): 65–70. doi:10.1097/01.pas.0000213327.86992.d1. PMID 17197920.

External links

• FactorBook SUZ12