SWAP70

SWAP switching B-cell complex 70kDa subunit
PDB rendering based on 2dn6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DN6​
Identifiers
Symbols	SWAP70 ; HSPC321; SWAP-70
External IDs	OMIM: 604762 MGI: 1298390 HomoloGene: 7557 GeneCards: SWAP70 Gene
Gene ontology Molecular function • DNA binding • calcium ion binding • protein binding • ATP binding Cellular component • nucleus • cytosol • plasma membrane • lamellipodium Biological process • positive regulation of cytosolic calcium ion concentration • negative regulation of actin filament depolymerization • positive regulation of actin filament bundle assembly • regulation of protein localization • negative regulation of cell-cell adhesion mediated by integrin • isotype switching • actin filament bundle assembly • positive regulation of mast cell chemotaxis • negative regulation of peptidyl-serine dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23075	20947
Ensembl	ENSG00000133789	ENSMUSG00000031015
UniProt	Q9UH65	Q6A028
RefSeq (mRNA)	NM_001297714	NM_009302
RefSeq (protein)	NP_001284643	NP_033328
Location (UCSC)	Chr 11: 9.66 – 9.75 Mb	Chr 7: 110.22 – 110.28 Mb
PubMed search

Switch-associated protein 70 is a protein that in humans and other mammals is encoded by the SWAP70 gene.^[1][2][3][4]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D (Apr 2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc Natl Acad Sci U S A 97 (5): 2180–4. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448.
3. "Entrez Gene: SWAP70 SWAP-70 protein".
4. Pearce G, Angeli V, Randolph GJ, Junt T, von Andrian U, Schnittler HJ, Jessberger R (August 2006). "Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs". Nat. Immunol. 7 (8): 827–34. doi:10.1038/ni1365. PMID 16845395.

Further reading

• Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex.". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
• Rapalus L, Minegishi Y, Lavoie A, et al. (2002). "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency.". Clin. Immunol. 101 (3): 270–5. doi:10.1006/clim.2001.5116. PMID 11726218.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hilpelä P, Oberbanscheidt P, Hahne P, et al. (2004). "SWAP-70 identifies a transitional subset of actin filaments in motile cells.". Mol. Biol. Cell 14 (8): 3242–53. doi:10.1091/mbc.E03-01-0043. PMC 181564. PMID 12925760.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling.". J. Cell. Sci. 119 (Pt 3): 500–7. doi:10.1242/jcs.02767. PMID 16418221.
• Kimbara N, Dohi N, Miyamoto M, et al. (2006). "Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells.". Microbiol. Immunol. 50 (3): 235–42. doi:10.1111/j.1348-0421.2006.tb03790.x. PMID 16547421.
• Liu J, Li D, Cao B, et al. (2007). "Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation.". J. Histochem. Cytochem. 55 (7): 701–8. doi:10.1369/jhc.6A7151.2007. PMID 17371938.