SYCP3
| Synaptonemal complex protein 3 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SYCP3 ; COR1; SCP3; SPGF4 | ||||||||||||
| External IDs | OMIM: 604759 MGI: 109542 HomoloGene: 7964 GeneCards: SYCP3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 50511 | 20962 | |||||||||||
| Ensembl | ENSG00000139351 | ENSMUSG00000020059 | |||||||||||
| UniProt | Q8IZU3 | P70281 | |||||||||||
| RefSeq (mRNA) | NM_001177948 | NM_011517 | |||||||||||
| RefSeq (protein) | NP_001171419 | NP_035647 | |||||||||||
| Location (UCSC) |
Chr 12: 101.73 – 101.74 Mb |
Chr 10: 88.46 – 88.47 Mb | |||||||||||
| PubMed search | |||||||||||||
Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene.[1][2][3]
References
- ↑ Martinez-Garay I, Jablonka S, Sutajova M, Steuernagel P, Gal A, Kutsche K (Sep 2002). "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region". Genomics 80 (3): 259–67. doi:10.1006/geno.2002.6834. PMID 12213195.
- ↑ Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD (Aug 2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
- ↑ "Entrez Gene: SYCP3 synaptonemal complex protein 3".
Further reading
- Yuan L, Liu JG, Zhao J, et al. (2000). "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility". Mol. Cell 5 (1): 73–83. doi:10.1016/S1097-2765(00)80404-9. PMID 10678170.
- Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lee J, Iwai T, Yokota T, Yamashita M (2004). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". J. Cell. Sci. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
- Miyamoto T, Hasuike S, Yogev L, et al. (2004). "Azoospermia in patients heterozygous for a mutation in SYCP3". Lancet 362 (9397): 1714–9. doi:10.1016/S0140-6736(03)14845-3. PMID 14643120.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- de Boer P, Giele M, Lock MT, et al. (2004). "Kinetics of meiosis in azoospermic males: a joint histological and cytological approach". Cytogenet. Genome Res. 105 (1): 36–46. doi:10.1159/000078007. PMID 15218256.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stouffs K, Lissens W, Tournaye H, et al. (2006). "SYCP3 mutations are uncommon in patients with azoospermia". Fertil. Steril. 84 (4): 1019–20. doi:10.1016/j.fertnstert.2005.04.033. PMID 16213863.
- Aarabi M, Modarressi MH, Soltanghoraee H, et al. (2006). "Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia". Fertil. Steril. 86 (2): 325–31. doi:10.1016/j.fertnstert.2005.12.070. PMID 16824523.
- Sapkota G, Knockaert M, Alarcón C, et al. (2007). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". J. Biol. Chem. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.
- Martínez J, Bonache S, Carvajal A, et al. (2007). "Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest". Fertil. Steril. 88 (4): 988–9. doi:10.1016/j.fertnstert.2006.11.163. PMID 17434513.
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