SYNJ2
| Synaptojanin 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SYNJ2 ; INPP5H | ||||||||||||
| External IDs | OMIM: 609410 HomoloGene: 117703 IUPHAR: 1462 GeneCards: SYNJ2 Gene | ||||||||||||
| EC number | 3.1.3.36 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8871 | 20975 | |||||||||||
| Ensembl | ENSG00000078269 | ENSMUSG00000023805 | |||||||||||
| UniProt | O15056 | Q9D2G5 | |||||||||||
| RefSeq (mRNA) | NM_001178088 | NM_001113351 | |||||||||||
| RefSeq (protein) | NP_001171559 | NP_001106822 | |||||||||||
| Location (UCSC) |
Chr 6: 157.98 – 158.1 Mb |
Chr 17: 5.94 – 6.04 Mb | |||||||||||
| PubMed search | |||||||||||||
Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene. [1]
Function
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
References
- ↑ "Entrez Gene: Synaptojanin 2". Retrieved 2014-06-24.
Further reading
- Luciano, M; Lopez, L. M.; De Moor, M. H.; Harris, S. E.; Davies, G; Nutile, T; Krueger, R. F.; Esko, T; Schlessinger, D; Toshiko, T; Derringer, J. L.; Realo, A; Hansell, N. K.; Pergadia, M. L.; Pesonen, A. K.; Sanna, S; Terracciano, A; Madden, P. A.; Penninx, B; Spinhoven, P; Hartman, C. A.; Oostra, B. A.; Janssens, A. C.; Eriksson, J. G.; Starr, J. M.; Cannas, A; Ferrucci, L; Metspalu, A; Wright, M. J.; et al. (2012). "Longevity candidate genes and their association with personality traits in the elderly". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B (2): 192–200. doi:10.1002/ajmg.b.32013. PMC 3583011. PMID 22213687.
- Verweij, K. J.; Vinkhuyzen, A. A.; Benyamin, B; Lynskey, M. T.; Quaye, L; Agrawal, A; Gordon, S. D.; Montgomery, G. W.; Madden, P. A.; Heath, A. C.; Spector, T. D.; Martin, N. G.; Medland, S. E. (2013). "The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation". Addiction Biology 18 (5): 846–50. doi:10.1111/j.1369-1600.2012.00478.x. PMC 3548058. PMID 22823124.
- Modregger, J; Schmidt, A. A.; Ritter, B; Huttner, W. B.; Plomann, M (2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". Journal of Biological Chemistry 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.
- Spaenij-Dekking, E. H.; Van Delft, J; Van Der Meijden, E; Hiemstra, H. S.; Falkenburg, J. H.; Koning, F; Drijfhout, J. W.; Kluin-Nelemans, J. C. (2003). "Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells". Leukemia 17 (12): 2467–73. doi:10.1038/sj.leu.2403174. PMID 14562116.
- Chuang, Y; Xu, X; Kwiatkowska, A; Tsapraillis, G; Hwang, H; Petritis, K; Flynn, D; Symons, M (2012). "Regulation of synaptojanin 2 5'-phosphatase activity by Src". Cell Adhesion & Migration 6 (6): 518–25. doi:10.4161/cam.22139. PMC 3547897. PMID 23076136.
- Wong, K. A.; Wilson, J; Russo, A; Wang, L; Okur, M. N.; Wang, X; Martin, N. P.; Scappini, E; Carnegie, G. K.; O'Bryan, J. P. (2012). "Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks". PLoS ONE 7 (4): e36023. doi:10.1371/journal.pone.0036023. PMC 3338775. PMID 22558309.
- Jiao, S; Hsu, L; Berndt, S; Bézieau, S; Brenner, H; Buchanan, D; Caan, B. J.; Campbell, P. T.; Carlson, C. S.; Casey, G; Chan, A. T.; Chang-Claude, J; Chanock, S; Conti, D. V.; Curtis, K. R.; Duggan, D; Gallinger, S; Gruber, S. B.; Harrison, T. A.; Hayes, R. B.; Henderson, B. E.; Hoffmeister, M; Hopper, J. L.; Hudson, T. J.; Hutter, C. M.; Jackson, R. D.; Jenkins, M. A.; Kantor, E. D.; Kolonel, L. N.; et al. (2012). "Genome-wide search for gene-gene interactions in colorectal cancer". PLoS ONE 7 (12): e52535. doi:10.1371/journal.pone.0052535. PMC 3530500. PMID 23300701.
- Warnatz, H. -J.; Schmidt, D.; Manke, T.; Piccini, I.; Sultan, M.; Borodina, T.; Balzereit, D.; Wruck, W.; Soldatov, A.; Vingron, M.; Lehrach, H.; Yaspo, M. -L. (2011). "The BTB and CNC Homology 1 (BACH1) Target Genes Are Involved in the Oxidative Stress Response and in Control of the Cell Cycle". Journal of Biological Chemistry 286 (26): 23521–23532. doi:10.1074/jbc.M111.220178. PMC 3123115. PMID 21555518.
- Chuang, Y. Y.; Tran, N. L.; Rusk, N; Nakada, M; Berens, M. E.; Symons, M (2004). "Role of synaptojanin 2 in glioma cell migration and invasion". Cancer Research 64 (22): 8271–5. doi:10.1158/0008-5472.CAN-04-2097. PMID 15548694.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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