SYTL2

Synaptotagmin-like 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BC1​
Identifiers
Symbols	SYTL2 ; CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2; SLP2A
External IDs	OMIM: 612880 MGI: 1933366 HomoloGene: 131343 GeneCards: SYTL2 Gene
Gene ontology Molecular function • phosphatidylserine binding • calcium ion binding • protein binding • calcium-dependent phospholipid binding • phosphatidylinositol-4,5-bisphosphate binding • Rab GTPase binding • phosphatase binding • syntaxin binding • clathrin binding • neurexin family protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • plasma membrane • membrane • extrinsic component of plasma membrane • melanosome • exocytic vesicle Biological process • intracellular protein transport • exocytosis • vesicle docking involved in exocytosis • negative regulation of phosphatase activity • synaptic vesicle exocytosis • vesicle-mediated transport • regulation of calcium ion-dependent exocytosis • calcium ion-dependent exocytosis of neurotransmitter • positive regulation of mucus secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54843	83671
Ensembl	ENSG00000137501	ENSMUSG00000030616
UniProt	Q9HCH5	Q99N50
RefSeq (mRNA)	NM_001162951	NM_001040085
RefSeq (protein)	NP_001156423	NP_001035174
Location (UCSC)	Chr 11: 85.69 – 85.81 Mb	Chr 7: 90.35 – 90.41 Mb
PubMed search

Synaptotagmin-like 2, also known as SYTL2, is a human gene.^[1]

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.^[1]

Interactions

SYTL2 has been shown to interact with RAB27A.^[2][3][4]

References

1. "Entrez Gene: SYTL2 synaptotagmin-like 2".
2. Fukuda, Mitsunori (Apr 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. (United States) 278 (17): 15390–6. doi:10.1074/jbc.M213090200. ISSN 0021-9258. PMID 12590134.
3. Strom, Molly; Hume Alistair N; Tarafder Abul K; Barkagianni Eleni; Seabra Miguel C (Jul 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. (United States) 277 (28): 25423–30. doi:10.1074/jbc.M202574200. ISSN 0021-9258. PMID 11980908.
4. Kuroda, Taruho S; Fukuda Mitsunori; Ariga Hiroyoshi; Mikoshiba Katsuhiko (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. (United States) 277 (11): 9212–8. doi:10.1074/jbc.M112414200. ISSN 0021-9258. PMID 11773082.

Further reading

• Nalefski EA, Falke JJ (1997). "The C2 domain calcium-binding motif: structural and functional diversity". Protein Sci. 5 (12): 2375–90. doi:10.1002/pro.5560051201. PMC 2143302. PMID 8976547.
• Duncan RR, Shipston MJ, Chow RH (2000). "Double C2 protein. A review". Biochimie 82 (5): 421–6. doi:10.1016/S0300-9084(00)00214-5. PMID 10865129.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Fukuda M, Mikoshiba K (2001). "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins". Biochem. Biophys. Res. Commun. 281 (5): 1226–33. doi:10.1006/bbrc.2001.4512. PMID 11243866.
• Fukuda M, Saegusa C, Mikoshiba K (2001). "Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain". Biochem. Biophys. Res. Commun. 283 (2): 513–9. doi:10.1006/bbrc.2001.4803. PMID 11327731.
• Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
• Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Yu M, Kasai K, Nagashima K, et al. (2007). "Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain". Mol. Biol. Cell 18 (2): 688–96. doi:10.1091/mbc.E06-10-0914. PMC 1783794. PMID 17182843.