Satratoxin-H

Satratoxin-H
Names
IUPAC name
(2'R,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-6,7,16,16a,19a,22-

hexahydro-25-hydroxy-9-((1S)-1-hydroxyethyl)-16a,21-dimethyl-spiro(5,9,16,18-dimethano- 1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H)-2'-oxirane)-

3,14(9H)-dione
Identifiers
53126-64-0 N
ChemSpider 16736977 YesY
Jmol interactive 3D Image
PubChem 6438478
Properties
C29H36O9
Molar mass 528.591
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Satratoxin-H, a trichothecene mycotoxin, is a naturally occurring mold byproduct of Stachybotrys chartarum which is toxic to humans and animals. The clinical condition it causes is known as Stachybotrotoxicosis. It is related to the mycotoxin T-2, but unlike T-2 has not been reported to have been used as a biological weapon.

Properties

Satratoxin-H is almost completely insoluble in water, but is easily soluble in lower alcohols and polar solvents such as ethanol, methanol, isopropanol (rubbing alcohol), acetone and chloroform.[1]

Satratoxin-H is not officially classified as a chemical weapon.

Effects

Satratoxin-H is extremely versatile. Contact with the solution through ingestion, inhalation, or even physical contact produces symptoms similar to those listed below.

However, if consumed in large quantities, it can be lethal. Satratoxin-H has little effect on bare skin, and does not blister in the way many chemical weapons do. However, upon sensitive surfaces (eyes, interior of mouth or nose), it can irritate the skin or cause a rash.

The toxicology of satratoxin-H shows that it has an LD50 for mice of 1.0-1.4 mg/kg, upon injection. Otherwise it is reported to be about five times as toxic as the T-2 toxin.[2]

References

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