Schüffner's dots

Trophozoites of P. ovale in thin blood smears. Schüffner's dots can be seen.

Schüffner's dots refers to a hematological finding that is associated with malaria,^[1] exclusively found in Plasmodium ovale and Plasmodium vivax.^[2]

Plasmodium vivax induces morphologic alterations in infected host erythrocytes that are visible by light microscopy in Romanovsky-stained blood smears as multiple brick-red dots. These morphologic changes, referred to as Schüffner's dots, are important in the identification of this species of malarial parasite and have been associated by electron microscopy with caveolavesicle complexes along the erythrocyte plasmalemma.^[3]

They are named for Wilhelm Schüffner, who described them in 1904.^[4]

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Eponymous medical signs for infectious disease

Bacterial disease	syphilis Hutchinson's teeth Hutchinson's triad Abelin reaction Westphal's sign Clutton's joints Dennie-Marfan syndrome

Viral disease	measles Koplik's spots Warthin-Finkeldey cell yellow fever Councilman body Tzanck test Inclusion bodies: poxvirus Downie bodies/A Guarnieri bodies/B rabies Negri bodies Cowdry bodies Liebermeister's rule Faget sign

Parasitic disease	Chagas disease (Romana's sign) African trypanosomiasis (Winterbottom's sign) malaria (Schüffner's dots)

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