Plunc

BPI fold containing family A, member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BPIFA1 ; LUNX; NASG; PLUNC; SPLUNC1; SPURT; bA49G10.5
External IDs OMIM: 607412 MGI: 1338036 HomoloGene: 7895 GeneCards: BPIFA1 Gene
Orthologs
Species Human Mouse
Entrez 51297 18843
Ensembl ENSG00000198183 ENSMUSG00000027483
UniProt Q9NP55 P97361
RefSeq (mRNA) NM_001243193 NM_011126
RefSeq (protein) NP_001230122 NP_035256
Location (UCSC) Chr 20:
33.24 – 33.24 Mb
Chr 2:
154.14 – 154.15 Mb
PubMed search

Palate, lung, and nasal epithelium clone protein[1] (PLUNC) is a gene encoding a secretory protein. It is also called Secretory protein in upper respiratory tracts (SPURT). In humans, it is encoded by the BPIFA1 gene, previously called PLUNC.[2][3]

Function

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the airways and nasopharyngeal regions. Plunc inhibits the epithelial sodium channel (ENaC),[4] and also has anti-microbial functions.[5] As such, plunc is believed to play a role in innate immune defense in the airways. PLUNC's ability to regulate ENaC is pH-sensitive and fails in acidic cystic fibrosis airways.[6] Thus, defective PLUNC1 function is thought to contribute to the development of lung pathology in cystic fibrosis patients.

It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer..[7]

References

  1. Ghafouri, B. "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. Retrieved 13 June 2013.
  2. Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica Et Biophysica Acta 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.
  3. Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, Yokouchi H, Ozaki K, Monden M, Tanigami A (Feb 2001). "Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer". International Journal of Cancer. Journal International Du Cancer 91 (4): 433–7. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1059>3.0.CO;2-B. PMID 11251963.
  4. Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R (Jul 2009). "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage". Proceedings of the National Academy of Sciences of the United States of America 106 (27): 11412–7. doi:10.1073/pnas.0903609106. PMC 2708735. PMID 19541605.
  5. 6
  6. Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R (Oct 2013). "Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways". Proceedings of the National Academy of Sciences of the United States of America 110 (40): 15973–8. doi:10.1073/pnas.1311999110. PMC 3791714. PMID 24043776.
  7. "Entrez Gene: PLUNC".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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