Signal peptidase I

Signal peptidase I
Identifiers
EC number 3.4.21.89
CAS number 65979-36-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Signal peptidase I (EC 3.4.21.89, leader peptidase I, signal proteinase, Escherichia coli leader peptidase, eukaryotic signal peptidase, eukaryotic signal proteinase, leader peptidase, leader peptide hydrolase, leader proteinase, signal peptidase, pilin leader peptidase, SPC, prokaryotic signal peptidase, prokaryotic leader peptidase, HOSP, prokaryotic signal proteinase, propeptidase, PuIO prepilin peptidase, signal peptide hydrolase, signal peptide peptidase, signalase, bacterial leader peptidase 1) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

Cleavage of hydrophobic, N-terminal signal or leader sequences

This enzyme is present in bacterial membranes and in chloroplast thylakoid membranes.

References

  1. ↑ Black, M.T. (1993). "Evidence that the catalytic activity of prokaryote leader peptidase depends upon the operation of a serine-lysine catalytic dyad". J. Bacteriol. 175 (16): 4957–4961. PMID 8394311.
  2. ↑ Nunnari, J., Fox, T.D. and Walter, P. (1993). "A mitochondrial protease with two catalytic subunits of nonoverlapping specificities". Science 262 (5142): 1997–2004. doi:10.1126/science.8266095. PMID 8266095.
  3. ↑ Tschantz, W.R., Sung, M., Delgado-Partin, V.M. and Dalbey, R.E. (1993). "A serine and a lysine residue implicated in the catalytic mechanism of the Escherichia coli leader peptidase". J. Biol. Chem. 268 (36): 27349–27354. PMID 8262975.
  4. ↑ Lively, M.O., Newsome, A.L. and Nusier, M. (1994). "Eukaryote microsomal signal peptidases". Methods Enzymol. 244: 301–314. doi:10.1016/0076-6879(94)44024-7. PMID 7845216.
  5. ↑ Tschantz, W.R. and Dalbey, R.E. (1994). "Bacterial leader peptidase I". Methods Enzymol. 244: 285–301. doi:10.1016/0076-6879(94)44023-9. PMID 7845215.
  6. ↑ Chaal, B.K., Mould, R.M., Barbrook, A.C., Gray, J.C. and Howe, C.J. (1998). "Characterization of a cDNA encoding the thylakoidal processing peptidase from Arabidopsis thaliana. Implications for the origin and catalytic mechanism of the enzyme". J. Biol. Chem. 273 (2): 689–692. doi:10.1074/jbc.273.2.689. PMID 9422718.
  7. ↑ Inoue, K., Baldwin, A.J., Shipman, R.L., Matsui, K., Theg, S.M. and Ohme-Takagi, M. (2005). "Complete maturation of the plastid protein translocation channel requires a type I signal peptidase". J. Cell Biol. 171: 425–430. doi:10.1083/jcb.200506171. PMID 16275749.

External links

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