STAT5B

Signal transducer and activator of transcription 5B
PDB rendering based on 1y1u.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1y1u​
Identifiers
Symbols	STAT5B ; STAT5
External IDs	OMIM: 604260 MGI: 103035 HomoloGene: 55718 ChEMBL: 5817 GeneCards: STAT5B Gene
Gene ontology Molecular function • RNA polymerase II core promoter sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • signal transducer activity • protein binding • protein phosphatase binding • glucocorticoid receptor binding • protein dimerization activity Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • allantoin metabolic process • luteinization • natural killer cell differentiation • citrate metabolic process • 2-oxoglutarate metabolic process • succinate metabolic process • oxaloacetate metabolic process • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • isoleucine metabolic process • valine metabolic process • creatine metabolic process • fatty acid metabolic process • JAK-STAT cascade • female pregnancy • lactation • regulation of steroid metabolic process • taurine metabolic process • lipid storage • regulation of epithelial cell differentiation • response to estradiol • positive regulation of natural killer cell proliferation • positive regulation of natural killer cell differentiation • cellular response to hormone stimulus • T cell differentiation in thymus • prolactin signaling pathway • regulation of multicellular organism growth • positive regulation of multicellular organism growth • positive regulation of activated T cell proliferation • progesterone metabolic process • T cell homeostasis • negative regulation of apoptotic process • positive regulation of interleukin-2 biosynthetic process • positive regulation of B cell differentiation • positive regulation of gamma-delta T cell differentiation • negative regulation of erythrocyte differentiation • positive regulation of mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • positive regulation of natural killer cell mediated cytotoxicity • creatinine metabolic process • development of secondary female sexual characteristics • development of secondary male sexual characteristics • Peyer's patch development • positive regulation of inflammatory response • JAK-STAT cascade involved in growth hormone signaling pathway • response to interleukin-2 • response to interleukin-4 • response to interleukin-15 • cellular response to growth factor stimulus • cellular response to epidermal growth factor stimulus • mast cell migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6777	20851
Ensembl	ENSG00000173757	ENSMUSG00000020919
UniProt	P51692	P42232
RefSeq (mRNA)	NM_012448	NM_001113563
RefSeq (protein)	NP_036580	NP_001107035
Location (UCSC)	Chr 17: 42.2 – 42.28 Mb	Chr 11: 100.78 – 100.85 Mb
PubMed search

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.^[1] STAT5B orthologs ^[2] have been identified in most placentals for which complete genome data are available.

Function

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.^[3]

Interactions

STAT5B has been shown to interact with:

• Glucocorticoid receptor,^[4]
• Janus kinase 1,^[5]
• Janus kinase 2,^[5][6] and
• PTPN11.^[7]

See also

• STAT5

References

1. Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883.
2. "OrthoMaM phylogenetic marker: STAT5B coding sequence".
3. "Entrez Gene: STAT5B signal transducer and activator of transcription 5B".
4. Stöcklin E, Wissler M, Gouilleux F, Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid receptor". Nature 383 (6602): 726–8. doi:10.1038/383726a0. PMID 8878484.
5. Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382.
6. Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. 273 (20): 12567–75. doi:10.1074/jbc.273.20.12567. PMID 9575217.
7. Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. 275 (1): 599–604. doi:10.1074/jbc.275.1.599. PMID 10617656.

Further reading

• Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1-2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.