Sjogren syndrome antigen B

Sjogren syndrome antigen B (autoantigen La)
PDB rendering based on 1owx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1OWX​, 1S79​, 1S7A​, 1YTY​, 1ZH5​, 2VOD​, 2VON​, 2VOO​, 2VOP​
Identifiers
Symbols	SSB ; LARP3; La; La/SSB
External IDs	OMIM: 109090 MGI: 98423 HomoloGene: 2366 GeneCards: SSB Gene
Gene ontology Molecular function • tRNA binding • nucleotide binding • mRNA binding • protein binding • poly(A) RNA binding Cellular component • nucleus • ribonucleoprotein complex Biological process • tRNA modification • histone mRNA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6741	20823
Ensembl	ENSG00000138385	ENSMUSG00000068882
UniProt	P05455	P32067
RefSeq (mRNA)	NM_001294145	NM_001110145
RefSeq (protein)	NP_001281074	NP_001103615
Location (UCSC)	Chr 2: 169.79 – 169.81 Mb	Chr 2: 69.86 – 69.87 Mb
PubMed search

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.^[1]

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.^[1][2]

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.^[3]

References

1. "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)".
2. Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (January 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Mol. Cell 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMID 16387655.
3. Fouraux, Michael A; Bouvet Philippe; Verkaart Sjoerd; van Venrooij Walther J; Pruijn Ger J M (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". J. Mol. Biol. (England) 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. ISSN 0022-2836. PMID 12096904.

Further reading

• Kohsaka H, Yamamoto K, Fujii H, et al. (1990). "Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein.". J. Clin. Invest. 85 (5): 1566–74. doi:10.1172/JCI114606. PMC 296607. PMID 1692037.
• Sturgess AD, Peterson MG, McNeilage LJ, et al. (1988). "Characteristics and epitope mapping of a cloned human autoantigen La.". J. Immunol. 140 (9): 3212–8. PMID 2452201.
• Rauh AJ, Hornig H, Lührmann R (1989). "At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach.". Eur. J. Immunol. 18 (12): 2049–57. doi:10.1002/eji.1830181227. PMID 2464497.
• Chan EK, Sullivan KF, Tan EM (1989). "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.". Nucleic Acids Res. 17 (6): 2233–44. doi:10.1093/nar/17.6.2233. PMC 317593. PMID 2468131.
• Gottlieb E, Steitz JA (1989). "Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III.". EMBO J. 8 (3): 851–61. PMC 400884. PMID 2470590.
• Chambers JC, Kenan D, Martin BJ, Keene JD (1989). "Genomic structure and amino acid sequence domains of the human La autoantigen.". J. Biol. Chem. 263 (34): 18043–51. PMID 3192525.
• Chambers JC, Keene JD (1985). "Isolation and analysis of cDNA clones expressing human lupus La antigen.". Proc. Natl. Acad. Sci. U.S.A. 82 (7): 2115–9. doi:10.1073/pnas.82.7.2115. PMC 397503. PMID 3856888.
• Svitkin YV, Pause A, Sonenberg N (1994). "La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.". J. Virol. 68 (11): 7001–7. PMC 237137. PMID 7933082.
• Tröster H, Metzger TE, Semsei I, et al. (1994). "One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome.". J. Exp. Med. 180 (6): 2059–67. doi:10.1084/jem.180.6.2059. PMC 2191769. PMID 7964483.
• Fan H, Sakulich AL, Goodier JL, et al. (1997). "Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes.". Cell 88 (5): 707–15. doi:10.1016/S0092-8674(00)81913-3. PMID 9054510.
• McLaren RS, Caruccio N, Ross J (1997). "Human La protein: a stabilizer of histone mRNA.". Mol. Cell. Biol. 17 (6): 3028–36. PMC 232155. PMID 9154801.
• Grölz D, Bachmann M (1997). "The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs.". Biochem. J. 323 (1): 151–8. PMC 1218288. PMID 9173875.
• Helsloot J, Sturgess A (1998). "T cell reactivity to Sjögren's syndrome related antigen La(SSB).". J. Rheumatol. 24 (12): 2340–7. PMID 9415639.
• Broekhuis CH, Neubauer G, van der Heijden A, et al. (2000). "Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution.". Biochemistry 39 (11): 3023–33. doi:10.1021/bi992308c. PMID 10715123.
• Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities.". Virology 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.
• Intine RV, Sakulich AL, Koduru SB, et al. (2000). "Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366.". Mol. Cell 6 (2): 339–48. doi:10.1016/S1097-2765(00)00034-4. PMID 10983981.
• Nashimoto M, Nashimoto C, Tamura M, et al. (2001). "The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs.". J. Mol. Biol. 312 (5): 975–84. doi:10.1006/jmbi.2001.5026. PMID 11580243.
• De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM (2002). "Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA.". Virology 295 (2): 337–47. doi:10.1006/viro.2002.1407. PMID 12033793.
• Intine RV, Dundr M, Misteli T, Maraia RJ (2002). "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs.". Mol. Cell 9 (5): 1113–23. doi:10.1016/S1097-2765(02)00533-6. PMID 12049746.
• Fouraux MA, Bouvet P, Verkaart S, et al. (2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes.". J. Mol. Biol. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904.