Vesiculobullous disease

Vesiculobullous disease
Diagram showing cross section of vesicles (left) and bullae (right) on skin.
Classification and external resources
Specialty	dermatology
ICD-10	L10-L14
ICD-9-CM	694
MeSH	D012872

A vesiculobullous disease is a type of mucocutaneous disease that is characterized by vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5-10 mm and bulla being larger than 5-10 mm, depending upon what definition is used). In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous,^[1] is sometimes used. Example vesiculobullous diseases include:

• Infectious: (viral)
  • Herpes simplex
  • Varicella-Zoster infection
  • Hand, foot and mouth disease
  • Herpangina
  • Measles (Rubeola)
• Immunobullous:
  • Pemphigus vulgaris^[2]
  • Pemphigoid
  • Dermatitis herpetiformis
  • Linear immunoglobulin-A disease (linear IgA disease)
• Genetic:
  • Epidermolysis bullosa^[3]

Some features are as follows:

Name	Acantholysis?	Ig
epidermolysis bullosa	yes	mostly IgG
bullous pemphigoid	no	mostly IgG
dermatitis herpetiformis	no	IgA

References

1. Magro, C. M.; Roberts-Barnes, J.; Crowson, A. N. (2012). "Direct Immunofluorescence Testing in the Diagnosis of Immunobullous Disease, Collagen Vascular Disease, and Vascular Injury Syndromes". Dermatologic Clinics 30 (4): 763–798, viii. doi:10.1016/j.det.2012.06.008. PMID 23021058.
2. Williams DM (December 1989). "Vesiculobullous mucocutaneous disease: pemphigus vulgaris". J. Oral Pathol. Med. 18 (10): 544–53. PMID 2695619.
3. Rao R, Prabhu SS, Sripathi H, Gupta S (2008). "Vesiculobullous lesions in lipoid proteinosis: a case report". Dermatol. Online J. 14 (7): 16. PMID 18718200.