Spermine synthase

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Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine.^[1]^[2] This enzyme catalyses the following chemical reaction

S-adenosylmethioninamine + spermidine

\rightleftharpoons

S-methyl-5'-thioadenosine + spermine

References

↑ Hibasami, H., Borchardt, R.T., Chen, S.-Y., Coward, J.K. and Pegg, A.E. (1980). "Studies of inhibition of rat spermidine synthase and spermine synthase". Biochem. J. 187 (2): 419–428. PMC 1161808. PMID 7396856.
↑ Pajula, R.-L., Raina, A. and Eloranta, T. (1979). "Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain". Eur. J. Biochem. 101 (2): 619–626. doi:10.1111/j.1432-1033.1979.tb19756.x. PMID 520313.

External links

Spermine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
EC 2.5.1.22
SMS

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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