Sphincter of Oddi
| sphincter of Oddi | |
|---|---|
 Interior of the descending portion of the duodenum, showing bile papilla. | |
| Details | |
| Identifiers | |
| Latin | m. sphincter ampullae |
| MeSH | A03.159.183.079.300.900.600 |
| Dorlands /Elsevier | s_18/12748595 |
| TA | A05.8.02.018 |
| FMA | 15077 |
The sphincter of Oddi (or hepatopancreatic sphincter) is a muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. It is named after Ruggero Oddi.[1] The sphincter of Oddi is relaxed by the hormone cholecystokinin (CCK)[2] via vasoactive intestinal peptide (VIP).[3]
Clinical significance
Main article: sphincter of Oddi dysfunction
Opiates can cause spasms of the sphincter of Oddi, leading to increased serum amylase levels.
Other animals
In many mammals (including mice, guinea pigs, dogs and opossums), the smooth muscle around the ampulla of Vater does not form a sphincter.[4]
References
- ↑ synd/2709 at Who Named It?
- ↑ Board Review Series (5th ed.). Lippincott Williams & Wilkins medical. March 2006. p. 220. ISBN 978-0781798761.
- ↑ Wiley, J W; O'Dorisio, T M; Owyang, C (1988). "Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi". Journal of Clinical Investigation 81 (6): 1920–4. doi:10.1172/JCI113539. PMC 442644. PMID 3384954.
- ↑ Higashiyama H, Sumitomo H, Ozawa A, Igarashi H, Tsunekawa N, Kurohmaru M, Kanai Y. (2016). Anatomy of the Murine Hepatobiliary System: A Whole-Organ-Level Analysis Using a Transparency Method. The Anatomical Record. 299(2):161-172. doi:10.1002/ar.23287 PMID 26559382
- Gray's Anatomy, 39th ed. p. 1228.
Further reading
- Ballal, M. A.; Sanford, P. A. (2000). "Physiology of the sphincter of Oddi--the present and the future?--Part 1". Saudi Journal of Gastroenterology 6 (3): 129–46. PMID 19864708.
- Ballal, M. A.; Sanford, P. A. (2001). "Physiology of the sphincter of Oddi: The present and the future?--Part 2". Saudi Journal of Gastroenterology 7 (1): 6–21. PMID 19861760.
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