Franklin Stahl

Franklin William Stahl
Born (1929-10-08) October 8, 1929
Boston, Massachusetts
Residence Eugene, Oregon, USA
Citizenship USA
Nationality United States
Fields Molecular biology
Genetics
Institutions University of Oregon
Alma mater Harvard University (A.B., 1951)
University of Rochester (Ph.D., 1956)
Known for Meselson-Stahl experiment

Franklin (Frank) William Stahl (born October 8, 1929) is an American molecular biologist and geneticist. With Matthew Meselson, Stahl conducted the famous Meselson-Stahl experiment showing that DNA is replicated by a semiconservative mechanism, meaning that each strand of the DNA serves as a template for production of a new strand.

He is Emeritus Professor of Biology[1] at the University of Oregon's Institute of Molecular Biology in Eugene, Oregon.

Career

Stahl, like his two older sisters, graduated from the public schools of Needham, a Boston suburb. In 1951, he was awarded an AB degree in biology from Harvard College, and matriculated in the biology department of the University of Rochester. His interest in genetics was cemented in 1952 by his introduction to bacterial viruses (phages) in a course taught by A. H. (Gus) Doermann at the Cold Spring Harbor Biological Laboratory. In 1956, he received a PhD in biology for his work with Doermann on the genetics of T4 phage. In 1955, he undertook postdoctoral studies with Giuseppe Bertani (in the Phage group) at Caltech (Pasadena) with the aim of learning some bacterial genetics. He subsequently turned his attentions to collaborations with Charley Steinberg and Matt Meselson. With Steinberg, he undertook mathematical analyses of T4 growth, mutation, and genetic recombination. With Meselson, he studied DNA replication in Escherichia coli. That study produced strong support for the semiconservative model proposed by Jim Watson and Francis Crick.[2]

For one year, Stahl served on the zoology faculty at the University of Missouri in Columbia, Missouri before accepting, in 1959, a position in the new Institute of Molecular Biology at the University of Oregon in Eugene. In the succeeding years, his research involved the phages T4 and Lambda and the budding yeast, Saccharomyces cerevisiae, with his primary focus on genetic recombination. He taught various genetics courses at Oregon and presented phage courses in America, Italy and India. He undertook sabbatical studies in Cambridge, UK, Edinburgh, Jerusalem, and Cambridge, Massachusetts.[2]

Stahl's research was undertaken in association with numerous colleagues, especially his long-tem associates Jean M. Crasemann (1921–1992), Mary M. Stahl (1935–1996), and Henriette (Jette) M. Foss (1937–date).[2] Since his retirement in 2001, he lives with Jette and four llamas in Eugene, where he continues to submit research papers and participates in University of Oregon governance.

Personal life

Stahl and his wife Mary (married in 1955) raised two boys and a girl. Surviving are Andy Stahl, a forester and political activist, and Emily Morgan, a hairdresser and shop owner. With his partner, Jette, he shares five children (plus spouses) and eight grandchildren, of whom five are adopted.[2]

Experimental contributions

In bacteria:

In phage T4:

In Lambda:

In Yeast:

Theoretical contributions

Selected honors

1997- Fellow, American Academy of Microbiology

1996 Thomas Hunt Morgan Medal (from Genetics Society of America)

1986- Associate Member EMBO

1985- American Cancer Society Research Professor

1985-1990 MacArthur Fellow

1981- Member, American Academy of Arts and Sciences

1976- Member, National Academy of Science

1975-76; 1985-1986 Guggenheim Fellow

1969-70 NIH Special Postdoctoral Fellowship

Honorary Doctor of Science: Oakland University and University of Rochester

References

  1. ↑ http://www.molbio.uoregon.edu/facres/stahl.html Archived September 7, 2006 at the Wayback Machine
  2. 1 2 3 4 Drake, J W (January 1997). "The 1996 Thomas Hunt Morgan Medal Franklin W. Stahl". Genetics 145 (1): 1–2. PMC 1207768. PMID 9017382.
  3. ↑ Meselson, M., and F.W. Stahl, 1958 The replication of DNA in Escherichia coli. Proc. Natl. Acad. Sci. USA 44: 671-682.
  4. ↑ Stahl, F.W., 1968 Role of recombination in the life cycle of bacteriophage T4. In "Replication and Recombination of Genetic Material," Australian Academy of Science, Canberra, pp. 206-215.
  5. ↑ Stahl, F.W., J. M. Crasemann, C. Yegian, M. M. Stahl and A. Nakata, 1970 Co-transcribed cistrons in bacteriophage T4. Genetics 64: 157-170.
  6. ↑ Stahl, F.W., 2005 Chi: a little sequence controls a big enzyme. A Perspective. Genetics 170: 487-493.
  7. ↑ Stahl, F. W., 1998 Recombination in phage : one geneticist's historical perspective. Gene 223: 95-102.
  8. ↑ Stahl, F. W. and H. M. Foss, 2010 A two-pathway analysis of meiotic crossing over and gene conversion in Saccharomyces cerevisiae. Genetics 186: 515–536.
  9. ↑ Steinberg, C. and F. Stahl, 1958 The theory of formal phage genetics. Cold Spring Harbor Symp. Quant. Biol. 23, 42-46.
  10. ↑ Szostak, J., T. L. Orr-Weaver, R. J. Rothstein and F.W. Stahl, 1983 The double-strand-break repair model for recombination. Cell 33: 25-35.
  11. ↑ Foss, E., R. Lande, F. W. Stahl, and C.M. Steinberg, 1993 Chiasma interference as a function of genetic distance. Genetics 133: 681-691.
  12. ↑ Stahl, F. W., and E. A. Housworth, 2009 Methods for analysis of crossover interference in S. cerevisiae. Methods Molec. Biol. 557: 35-53.
  13. ↑ Stahl, F., 2012 Defining and detecting crossover-interference mutants in yeast. PLoS ONE 7(6): e38476. doi:10.1371/journal.pone.0038476.

External links

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