Stictic acid
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| Names | |
|---|---|
| Systematic IUPAC name
1,4-Dihydroxy-10-methoxy-5,8-dimethyl-3,7-dioxo-1,3-dihydro-7H-2,6,12-trioxabenzo[5,6]cyclohepta[1,2-e]indene-11-carbaldehyde | |
| Identifiers | |
| 549-06-4 | |
| ChemSpider | 66327 |
| Jmol interactive 3D | Image |
| PubChem | 73677 |
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| Properties | |
| C19H14O9 | |
| Molar mass | 386.31 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Stictic acid is an aromatic organic compound, a product of secondary metabolism in some species of lichens.[1]
Stictic acid is the subject of medical research into cancer. Argentinian research showed that stictic acid extracted from Antarctic lichens has an apoptotic effect.[2] Subsequent cancer research has found that the compound has tumor suppressing effects via action on mutant p53 proteins in cancer cells.[3]
References
- ↑ Lohézic-Le Dévéhat, Françoise; Tomasi, Sophie; Elix, John A.; Bernard, Aurélie; Rouaud, Isabelle; Uriac, Philippe; Boustie, Joël (2007). "Stictic Acid Derivatives from the Lichen Usnea articulata and Their Antioxidant Activities". Journal of Natural Products 70 (7): 1218–20. doi:10.1021/np070145k. PMID 17629329.
- ↑ Correché, ER; Enriz, RD; Piovano, M; Garbarino, J; Gómez-Lechón, MJ (2004). "Cytotoxic and apoptotic effects on hepatocytes of secondary metabolites obtained from lichens". Alternatives to laboratory animals : ATLA 32 (6): 605–15. PMID 15757498.
- ↑ Wassman, Christopher D.; Baronio, Roberta; Demir, Özlem; Wallentine, Brad D.; Chen, Chiung-Kuang; Hall, Linda V.; Salehi, Faezeh; Lin, Da-Wei; Chung, Benjamin P.; Wesley Hatfield, G.; Richard Chamberlin, A.; Luecke, Hartmut; Lathrop, Richard H.; Kaiser, Peter; Amaro, Rommie E. (2013). "Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53". Nature Communications 4: 1407. doi:10.1038/ncomms2361. PMC 3562459. PMID 23360998.
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