Streptomyces toxytricini
| Streptomyces toxytricini | |
|---|---|
| Scientific classification | |
| Domain: | Bacteria |
| Phylum: | Actinobacteria |
| Order: | Actinomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. toxytricini |
| Binomial name | |
| Streptomyces toxytricini Preobrazhenskaya & Sveshnikova 1957 | |
Streptomyces toxytricini is a Gram-positive bacterium belonging to the genus Streptomyces. It produces the pancreatic lipase inhibitor lipstatin,[1] of which the antiobesity drug orlistat is a derivative.[2]
References
- ↑ Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987). "Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity". J Antibiot (Tokyo) 40 (8): 1081–5. doi:10.7164/antibiotics.40.1081. PMID 3680018.
- ↑ Barbier P, Schneider F (1987). "Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin". Helvetica Chimica Acta 70 (1): 196–202. doi:10.1002/hlca.19870700124.
Further reading
- Zhu, Tingheng; Wang, Lingfei; Wang, Weixia; Hu, Zhongce; Yu, Meilan; Wang, Kun; Cui, Zhifeng (April 3, 2014). "Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium". Journal of General and Applied Microbiology 60 (3): 106–111. doi:10.2323/jgam.60.106. PMID 25008166.
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