Succinate-semialdehyde dehydrogenase (acylating)

Succinate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP⁺ oxidoreductase (CoA-acylating).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

succinate semialdehyde + CoA + NADP⁺

\rightleftharpoons

succinyl-CoA + NADPH + H⁺

Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.

References

↑ Sohling, B. and Gottschalk, G. (1993). "Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri". Eur. J. Biochem. 212 (1): 121–127. doi:10.1111/j.1432-1033.1993.tb17641.x. PMID 8444151.
↑ Alber, B., Olinger, M., Rieder, A., Kockelkorn, D., Jobst, B., Hugler, M. and Fuchs, G. (2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp". J. Bacteriol. 188: 8551–8559. doi:10.1128/JB.00987-06. PMC 1698253. PMID 17041055.
↑ Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.

External links

Succinate-semialdehyde dehydrogenase (acylating) at the US National Library of Medicine Medical Subject Headings (MeSH)

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

1.2.7: iron-sulfur protein	Pyruvate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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