Sulfite reductase (NADPH)

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Sulfite reductase (NADPH) (EC 1.8.1.2, sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H₂S-NADP oxidoreductase, sulfite reductase (NADPH₂)) is an enzyme with systematic name hydrogen-sulfide:NADP⁺ oxidoreductase.^[1]^[2]^[3] This enzyme catalises the following chemical reaction

hydrogen sulfide + 3 NADP⁺ + 3 H₂O

\rightleftharpoons

sulfite + 3 NADPH + 3 H⁺

Sulfite reductase is an iron flavoprotein (FAD and FMN).

References

↑ Hilz, H., Kittler, M. and Knape, G. (1959). "Die Reduktion von Sulfate in der Hefe". Biochem. Z. 332: 151–166. PMID 14401842.
↑ Siegel, L.M., Murphy, M.J. and Kamin, H. (1973). "Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups". J. Biol. Chem. 248: 251–264. PMID 4144254.
↑ Yoshimoto, A. and Sato, R. (1968). "Studies on yeast sulfite reductase. I. Purification and characterization". Biochim. Biophys. Acta 153: 555–575. doi:10.1016/0005-2728(68)90185-0. PMID 4384979.

External links

Sulfite reductase (NADPH) at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: sulfur oxidoreductases (EC 1.8)

1.8.1: NAD or NADP	Dihydrolipoamide dehydrogenase Glutathione reductase Thioredoxin reductase

1.8.2: cytochrome	Sulfite dehydrogenase Thiosulfate dehydrogenase

1.8.3: oxygen	Sulfite oxidase

1.8.4: disulfide	Glutathione—homocystine transhydrogenase

1.8.5: quinone	Glutathione dehydrogenase (ascorbate)

1.8.98: Other, known	CoB—CoM heterodisulfide reductase

1.8.99: Other	Sulfite reductase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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