Sulfoacetaldehyde dehydrogenase (acylating)

Sulfoacetaldehyde dehydrogenase (acylating) (EC 1.2.1.81, SauS) is an enzyme with systematic name 2-sulfoacetaldehyde:NADP⁺ oxidoreductase (CoA-acetylating).^[1] This enzyme catalyses the following chemical reaction

2-sulfoacetaldehyde + CoA + NADP⁺

\rightleftharpoons

sulfoacetyl-CoA + NADPH + H⁺

The enzyme is involved in degradation of sulfoacetate.

References

↑ Weinitschke, S., Hollemeyer, K., Kusian, B., Bowien, B., Smits, T.H. and Cook, A.M. (2010). "Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16". J. Biol. Chem. 285 (46): 35249–35254. doi:10.1074/jbc.M110.127043. PMC 2975148. PMID 20693281.

External links

Sulfoacetaldehyde dehydrogenase (acylating) at the US National Library of Medicine Medical Subject Headings (MeSH)

Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP	Aldehyde dehydrogenase Acetaldehyde dehydrogenase Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome	Formate dehydrogenase (cytochrome)

1.2.3: oxygen	Aldehyde oxidase

1.2.4: disulfide	Oxoglutarate dehydrogenase complex Pyruvate dehydrogenase Branched-chain alpha-keto acid dehydrogenase complex BCKDHA BCKDHB DBT DLD

1.2.7: iron-sulfur protein	Pyruvate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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