Sulfur dioxygenase

Sulfur dioxygenase
Identifiers
EC number	1.13.11.18
CAS number	37256-58-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Sulfur dioxygenase (EC 1.13.11.18, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with systematic name S-sulfanylglutathione:oxygen oxidoreductase.^[1][2] This enzyme catalyses the following chemical reaction

sulfur + O₂ + H₂O $\rightleftharpoons$ sulfite + 2 H⁺ (overall reaction)

(1a) glutathione + sulfur $\rightleftharpoons$ S-sulfanylglutathione (spontaneous reaction)

(1b) S-sulfanylglutathione + O₂ + H₂O $\rightleftharpoons$ glutathione + sulfite + 2 H⁺

This enzyme contains iron.

In humans, sulfur dioxygenase is needed to detoxify sulfide.^[3]

References

1. Suzuki, I. and Silver, M. (1966). "The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli". Biochim. Biophys. Acta 122: 22–33. doi:10.1016/0926-6593(66)90088-9. PMID 5968172.
2. Rohwerder, T. and Sand, W. (2003). "The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp". Microbiology 149: 1699–1710. doi:10.1099/mic.0.26212-0. PMID 12855721.
3. Viscomi, C.; Burlina, A.B.; Dweikat, I.; Savoiardo, M.; Lamperti, C.; Hildebrandt, T.; Tiranti, V.; Zeviani, M. (2010). "Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy". Nat Med 16: 869–71. doi:10.1038/nm.2188. PMID 20657580.

External links

• Sulfur dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)