T1 holin family

The Phage T1 Holin (T1 Holin) Family (TC# 1.E.37) is represented in enterobacterial phages T1, RTP and F20, Klebsiella phage KP36, and Escherichia phage ADB-2. All of these possess a putative holin that share a high level of identity. Additionally, Gp9 of E. coli phage phiE49 is similar in sequence. These proteins are short, 55 to 71 amino acyl residues (aas) in length, and exhibit a single transmembrane segment (TMS).^[1] A representative list of proteins belonging to the T1 Holin family can be found in the Transporter Classification Database.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671.doi:10.1016/j.bbamem.2013.07.004. PMC 3788059.PMID 23856191.
• Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology 197(1): 7–17. doi:10.1128/JB.02046-14. ISSN 0021-9193.PMC 4288690. PMID 25157079.
• Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology 54: 799–825.doi:10.1146/annurev.micro.54.1.799. ISSN 0066-4227.PMID 11018145.
• Young, R.; Bläsi, U. (1995-08-01). "Holins: form and function in bacteriophage lysis". FEMS microbiology reviews 17 (1-2): 191–205. ISSN 0168-6445.PMID 7669346.

References

1. Catalão, Maria João; Gil, Filipa; Moniz-Pereira, José; São-José, Carlos; Pimentel, Madalena (2013-07-01). "Diversity in bacterial lysis systems: bacteriophages show the way". FEMS microbiology reviews 37 (4): 554–571. doi:10.1111/1574-6976.12006. ISSN 1574-6976. PMID 23043507.
2. "The Phage T1 Holin (T1 Holin) Family". TCDB. Retrieved 2016-03-28.

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