TACSTD2

Tumor-associated calcium signal transducer 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MAE​, 2MVK​, 2MVL​
Identifiers
Symbols	TACSTD2 ; EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1; TROP2
External IDs	OMIM: 137290 MGI: 1861606 HomoloGene: 1763 GeneCards: TACSTD2 Gene
Gene ontology Molecular function • receptor activity • protein binding Cellular component • extracellular space • nucleus • cytosol • integral component of plasma membrane • basal plasma membrane • membrane • lateral plasma membrane • extracellular exosome Biological process • cell surface receptor signaling pathway • visual perception • cell proliferation • negative regulation of epithelial cell migration • regulation of epithelial cell proliferation • negative regulation of stress fiber assembly • ureteric bud morphogenesis • negative regulation of branching involved in ureteric bud morphogenesis • negative regulation of substrate adhesion-dependent cell spreading • negative regulation of ruffle assembly • negative regulation of cell motility • positive regulation of stem cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4070	56753
Ensembl	ENSG00000184292	ENSMUSG00000051397
UniProt	P09758	Q8BGV3
RefSeq (mRNA)	NM_002353	NM_020047
RefSeq (protein)	NP_002344	NP_064431
Location (UCSC)	Chr 1: 58.58 – 58.58 Mb	Chr 6: 67.53 – 67.54 Mb
PubMed search

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),^[1] is a protein that in humans is encoded by the TACSTD2 gene.^[2][3][4]

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.^[4]

This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.

References

1. Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy
2. Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol 13 (3): 1507–15. PMC 359462. PMID 8382772.
3. Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet 92 (1-2): 164–5. doi:10.1159/000056891. PMID 11306819.
4. "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".

Further reading

• Linnenbach AJ, Wojcierowski J, Wu SA, et al. (1989). "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733.". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 27–31. doi:10.1073/pnas.86.1.27. PMC 286396. PMID 2911574.
• Fornaro M, Dell'Arciprete R, Stella M, et al. (1995). "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas.". Int. J. Cancer 62 (5): 610–8. doi:10.1002/ijc.2910620520. PMID 7665234.
• Elsewedy Electric T, Fornaro M, Alberti S (1998). "Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2.". Int. J. Cancer 75 (2): 324–30. doi:10.1002/(SICI)1097-0215(19980119)75:2<324::AID-IJC24>3.0.CO;2-B. PMID 9462726.
• Ripani E, Sacchetti A, Corda D, Alberti S (1998). "Human Trop-2 is a tumor-associated calcium signal transducer.". Int. J. Cancer 76 (5): 671–6. doi:10.1002/(SICI)1097-0215(19980529)76:5<671::AID-IJC10>3.0.CO;2-7. PMID 9610724.
• Tsujikawa M, Kurahashi H, Tanaka T, et al. (1999). "Identification of the gene responsible for gelatinous drop-like corneal dystrophy.". Nat. Genet. 21 (4): 420–3. doi:10.1038/7759. PMID 10192395.
• Nakamura T, Nishida K, Dota A, et al. (2000). "Gelatino-lattice corneal dystrophy: clinical features and mutational analysis.". Am. J. Ophthalmol. 129 (5): 665–6. doi:10.1016/S0002-9394(00)00369-X. PMID 10844062.
• Kinoshita S, Nishida K, Dota A, Abbie F, et al. (2000). "Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy.". Cornea 19 (4): 551–5. doi:10.1097/00003226-200007000-00029. PMID 10928776.
• Tsujikawa M, Tsujikawa K, Maeda N, et al. (2000). "Rapid detection of M1S1 mutations by the protein truncation test.". Invest. Ophthalmol. Vis. Sci. 41 (9): 2466–8. PMID 10937555.
• Ha NT, Fujiki K, Hotta Y, et al. (2000). "Q118X mutation of M1S1 gene caused gelatinous drop-like corneal dystrophy: the P501T of BIGH3 gene found in a family with gelatinous drop-like corneal dystrophy.". Am. J. Ophthalmol. 130 (1): 119–20. doi:10.1016/S0002-9394(00)00596-1. PMID 11004271.
• Tasa G, Kals J, Muru K, et al. (2001). "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy.". Invest. Ophthalmol. Vis. Sci. 42 (12): 2762–4. PMID 11687514.
• Yoshida S, Kumano Y, Yoshida A, et al. (2002). "Two brothers with gelatinous drop-like dystrophy at different stages of the disease: role of mutational analysis.". Am. J. Ophthalmol. 133 (6): 830–2. doi:10.1016/S0002-9394(02)01407-1. PMID 12036680.
• Ren Z, Lin PY, Klintworth GK, et al. (2002). "Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy.". Hum. Genet. 110 (6): 568–77. doi:10.1007/s00439-002-0729-z. PMID 12107443.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ha NT, Chau HM, Cung le X, et al. (2003). "A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy.". Am. J. Ophthalmol. 135 (3): 390–3. doi:10.1016/S0002-9394(02)01952-9. PMID 12614764.
• Gires O, Eskofier S, Lang S, et al. (2003). "Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter.". Anticancer Res. 23 (4): 3255–61. PMID 12926061.
• Tian X, Fujiki K, Li Q, et al. (2004). "Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy.". Am. J. Ophthalmol. 137 (3): 567–9. doi:10.1016/j.ajo.2003.08.008. PMID 15013888.
• Murakami A, Kimura S, Fujiki K, et al. (2004). "Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy.". Jpn. J. Ophthalmol. 48 (4): 317–20. doi:10.1007/s10384-003-0064-5. PMID 15295654.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.