TAF1A

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
Identifiers
Symbols	TAF1A ; MGC:17061; RAFI48; SL1; TAFI48
External IDs	OMIM: 604903 HomoloGene: 4155 GeneCards: TAF1A Gene
Gene ontology Molecular function • DNA binding • protein binding Cellular component • RNA polymerase I transcription factor complex • nucleus • nucleoplasm • microtubule cytoskeleton • intracellular membrane-bounded organelle Biological process • chromatin silencing at rDNA • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter • gene expression • regulation of gene expression, epigenetic • negative regulation of gene expression, epigenetic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9015	21339
Ensembl	ENSG00000143498	ENSMUSG00000072258
UniProt	Q15573	P97357
RefSeq (mRNA)	NM_001201536	NM_001277957
RefSeq (protein)	NP_001188465	NP_001264886
Location (UCSC)	Chr 1: 222.56 – 222.59 Mb	Chr 1: 183.39 – 183.41 Mb
PubMed search

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.^[1][2]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.^[2]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[3] and Protein SET.^[3]

References

1. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123. Check date values in: |year= / |date= mismatch (help)
2. "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
3. Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.

Further reading

• Rudloff U, Eberhard D, Tora L, Stunnenberg H, Grummt I (1994). "TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription". EMBO J. 13 (11): 2611–6. PMC 395135. PMID 8013460.
• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1-2): 133–6. doi:10.1159/000015592. PMID 10894955.
• Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.
• Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
• Dynes JL, Xu S, Bothner S, Lahti JM, Hori RT (2004). "The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors". J. Biochem. 135 (3): 429–38. doi:10.1093/jb/mvh051. PMID 15113842.
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.