TAF9B

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
Identifiers
Symbols	TAF9B ; DN-7; DN7; TAF9L; TAFII31L; TFIID-31
External IDs	OMIM: 300754 MGI: 3039562 HomoloGene: 47969 GeneCards: TAF9B Gene
Gene ontology Molecular function • transcription corepressor activity • protein binding • protein heterodimerization activity Cellular component • nucleoplasm • transcription factor TFIID complex • transcription factor TFTC complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • gene expression • viral process • positive regulation of cell growth • negative regulation of apoptotic process • protein stabilization • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51616	407786
Ensembl	ENSG00000187325	ENSMUSG00000047242
UniProt	Q9HBM6	Q6NZA9
RefSeq (mRNA)	NM_015975	NM_001001176
RefSeq (protein)	NP_057059	NP_001001176
Location (UCSC)	Chr X: 78.13 – 78.14 Mb	Chr X: 106.21 – 106.22 Mb
PubMed search

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.^[1][2]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.^[2]

References

1. Frontini M, Soutoglou E, Argentini M, Bole-Feysot C, Jost B, Scheer E, Tora L (May 2005). "TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9". Mol Cell Biol 25 (11): 4638–49. doi:10.1128/MCB.25.11.4638-4649.2005. PMC 1140618. PMID 15899866.
2. "Entrez Gene: TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa".

Further reading

• Albright SR, Tjian R (2000). "TAFs revisited: more data reveal new twists and confirm old ideas.". Gene 242 (1–2): 1–13. doi:10.1016/S0378-1119(99)00495-3. PMID 10721692.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen Z, Manley JL (2003). "In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L.". J. Biol. Chem. 278 (37): 35172–83. doi:10.1074/jbc.M304241200. PMID 12837753.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lu H, Levine AJ (1995). "Human TAFII31 protein is a transcriptional coactivator of the p53 protein.". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 5154–8. doi:10.1073/pnas.92.11.5154. PMC 41867. PMID 7761466.