TANK (gene)

TRAF family member-associated NFKB activator
Rendering of TANK from PDB 1KZZ​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1KZZ​, 1L0A​
Identifiers
Symbols	TANK ; I-TRAF; ITRAF; TRAF2
External IDs	OMIM: 603893 MGI: 107676 HomoloGene: 3081 GeneCards: TANK Gene
Gene ontology Molecular function • protein binding • ubiquitin protein ligase binding • metal ion binding Cellular component • cytoplasm • cytosol Biological process • toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • signal transduction • I-kappaB kinase/NF-kappaB signaling • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10010	21353
Ensembl	ENSG00000136560	ENSMUSG00000064289
UniProt	Q92844	P70347
RefSeq (mRNA)	NM_001199135	NM_001164071
RefSeq (protein)	NP_001186064	NP_001157543
Location (UCSC)	Chr 2: 161.14 – 161.24 Mb	Chr 2: 61.58 – 61.65 Mb
PubMed search

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.^[1][2][3]

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

TANK (gene) has been shown to interact with TANK-binding kinase 1,^[4][5] IKBKE,^[6] TRAF2,^[1][4][5][6] IKBKG^[7] and TRAF3.^[1][4]

References

1. Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (September 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proc Natl Acad Sci U S A 93 (16): 8241–6. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
2. Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G (November 1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein". Proc Natl Acad Sci U S A 93 (20): 11085–90. doi:10.1073/pnas.93.20.11085. PMC 38288. PMID 8855313.
3. "Entrez Gene: TANK TRAF family member-associated NFKB activator".
4. Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. Cite uses deprecated parameter |coauthors= (help)
5. Pomerantz, J L; Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. (ENGLAND) 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. ISSN 0261-4189. PMC 1171732. PMID 10581243.
6. Nomura, F; Kawai T; Nakanishi K; Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells (ENGLAND) 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. ISSN 1356-9597. PMID 10759890.
7. Chariot, Alain; Leonardi Antonio; Muller Jurgen; Bonif Marianne; Brown Keith; Siebenlist Ulrich (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. (United States) 277 (40): 37029–36. doi:10.1074/jbc.M205069200. ISSN 0021-9258. PMID 12133833.

Further reading

• Chin AI, Shu J, Shan Shi C, et al. (2000). "TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation through the Germinal Center Kinase Pathway". Mol. Cell. Biol. 19 (10): 6665–72. PMC 84649. PMID 10490605.
• Pomerantz JL, Baltimore D (2000). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". EMBO J. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
• Nomura F, Kawai T, Nakanishi K, Akira S (2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890.
• Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
• Li C, Ni CZ, Havert ML, et al. (2002). "Downstream regulator TANK binds to the CD40 recognition site on TRAF3". Structure 10 (3): 403–11. doi:10.1016/S0969-2126(02)00733-5. PMID 12005438.
• Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ishida R, Ezura Y, Emi M, et al. (2004). "Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women". Bone 33 (2): 237–41. doi:10.1016/S8756-3282(03)00226-6. PMID 14499357.
• Li C, Norris PS, Ni CZ, et al. (2004). "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling". J. Biol. Chem. 278 (50): 50523–9. doi:10.1074/jbc.M309381200. PMID 14517219.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bonif M, Meuwis MA, Close P, et al. (2006). "TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation". Biochem. J. 394 (Pt 3): 593–603. doi:10.1042/BJ20051659. PMC 1383709. PMID 16336209.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Guo B, Cheng G (2007). "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK". J. Biol. Chem. 282 (16): 11817–26. doi:10.1074/jbc.M700017200. PMID 17327220.
• Ryzhakov G, Randow F (2007). "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK". EMBO J. 26 (13): 3180–90. doi:10.1038/sj.emboj.7601743. PMC 1914091. PMID 17568778.
• Gatot JS, Gioia R, Chau TL, et al. (2007). "Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF". J. Biol. Chem. 282 (43): 31131–46. doi:10.1074/jbc.M701690200. PMID 17823124.

External links

• TANK human gene location in the UCSC Genome Browser.
• TANK human gene details in the UCSC Genome Browser.