TBL3
Transducin (beta)-like 3 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | TBL3 ; SAZD; UTP13 | ||||||||||||
External IDs | OMIM: 605915 MGI: 2384863 HomoloGene: 4711 GeneCards: TBL3 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 10607 | 213773 | |||||||||||
Ensembl | ENSG00000183751 | ENSMUSG00000040688 | |||||||||||
UniProt | Q12788 | Q8C4J7 | |||||||||||
RefSeq (mRNA) | NM_006453 | NM_145396 | |||||||||||
RefSeq (protein) | NP_006444 | NP_663371 | |||||||||||
Location (UCSC) |
Chr 16: 1.97 – 1.98 Mb |
Chr 17: 24.7 – 24.71 Mb | |||||||||||
PubMed search | |||||||||||||
Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.[1][2]
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.[2]
References
- ↑ Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.
- 1 2 "Entrez Gene: TBL3 transducin (beta)-like 3".
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
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