TBL3

Transducin (beta)-like 3
Identifiers
Symbols TBL3 ; SAZD; UTP13
External IDs OMIM: 605915 MGI: 2384863 HomoloGene: 4711 GeneCards: TBL3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10607 213773
Ensembl ENSG00000183751 ENSMUSG00000040688
UniProt Q12788 Q8C4J7
RefSeq (mRNA) NM_006453 NM_145396
RefSeq (protein) NP_006444 NP_663371
Location (UCSC) Chr 16:
1.97 – 1.98 Mb
Chr 17:
24.7 – 24.71 Mb
PubMed search

Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.[1][2]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.[2]

References

  1. Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.
  2. 1 2 "Entrez Gene: TBL3 transducin (beta)-like 3".

Further reading

This article is issued from Wikipedia - version of the Wednesday, September 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.