TCEA2

Transcription elongation factor A (SII), 2
PDB rendering based on 1tfi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LW4​
Identifiers
Symbols	TCEA2 ; TFIIS
External IDs	OMIM: 604784 MGI: 107368 HomoloGene: 68304 GeneCards: TCEA2 Gene
Gene ontology Molecular function • DNA binding • protein binding • zinc ion binding Cellular component • nucleoplasm • centrosome • transcription elongation factor complex Biological process • DNA-templated transcription, elongation • regulation of DNA-templated transcription, elongation • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6919	21400
Ensembl	ENSG00000171703	ENSMUSG00000059540
UniProt	Q15560	Q9QVN7
RefSeq (mRNA)	NM_003195	NM_009326
RefSeq (protein)	NP_003186	NP_033352
Location (UCSC)	Chr 20: 64.05 – 64.07 Mb	Chr 2: 181.68 – 181.69 Mb
PubMed search

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.^[1][2][3]

Function

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

TCEA2 has been shown to interact with MAGEA11.^[4]

References

1. Weaver ZA, Kane CM (Dec 1997). "Genomic characterization of a testis-specific TFIIS (TCEA2) gene". Genomics 46 (3): 516–9. doi:10.1006/geno.1997.5073. PMID 9441762.
2. Umehara T, Kida S, Yamamoto T, Horikoshi M (Dec 1995). "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II". Gene 167 (1-2): 297–302. doi:10.1016/0378-1119(95)00634-6. PMID 8566795.
3. "Entrez Gene: TCEA2 transcription elongation factor A (SII), 2".
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (Apr 1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes & Development 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
• Li XY, Green MR (Oct 1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes & Development 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC 317190. PMID 9765201.
• Trembley JH, Hu D, Hsu LC, Yeung CY, Slaughter C, Lahti JM, Kidd VJ (Jan 2002). "PITSLRE p110 protein kinases associate with transcription complexes and affect their activity". The Journal of Biological Chemistry 277 (4): 2589–96. doi:10.1074/jbc.M109755200. PMID 11709559.
• Sijbrandi R, Fiedler U, Timmers HT (Jun 2002). "RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage". Nucleic Acids Research 30 (11): 2290–8. doi:10.1093/nar/30.11.2290. PMC 117193. PMID 12034815.
• Saso K, Ito T, Natori S, Sekimizu K (Apr 2003). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". Journal of Biochemistry 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
• Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T (Sep 2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochemical and Biophysical Research Communications 309 (1): 189–95. doi:10.1016/S0006-291X(03)01556-0. PMID 12943681.
• Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (Nov 2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes to Cells 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Palangat M, Renner DB, Price DH, Landick R (Oct 2005). "A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS". Proceedings of the National Academy of Sciences of the United States of America 102 (42): 15036–41. doi:10.1073/pnas.0409405102. PMC 1257689. PMID 16214896.
• Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K (Jun 2007). "RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS". DNA Repair 6 (6): 841–51. doi:10.1016/j.dnarep.2007.01.014. PMID 17374514.