TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)

TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming) (EC 5.3.2.3, dTDP-6-deoxy-hex-4-ulose isomerase, TDP-6-deoxy-hex-4-ulose isomerase, FdtA) is an enzyme with systematic name dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose isomerase.^[1]^[2] This enzyme catalyses the following chemical reaction

dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose

\rightleftharpoons

dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose

The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose.

References

↑ Pfoestl, A., Hofinger, A., Kosma, P. and Messner, P. (2003). "Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α-D-galactose in Aneurinibacillus thermoaerophilus L420-91^T". J. Biol. Chem. 278: 26410–26417. doi:10.1074/jbc.m300858200. PMID 12740380.
↑ Davis, M.L., Thoden, J.B. and Holden, H.M. (2007). "The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase". J. Biol. Chem. 282: 19227–19236. doi:10.1074/jbc.m702529200. PMID 17459872.

External links

TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming) at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerases: intramolecular oxidoreductases (EC 5.3)

5.3.1: Aldoses/Ketoses	Triosephosphate isomerase Ribose-5-phosphate isomerase Mannose phosphate isomerase Glucose isomerase

5.3.2: Keto/Enol	Phenylpyruvate tautomerase Oxaloacetate tautomerase

5.3.3: C = C	Steroid D-isomerase Isopentenyl-diphosphate delta isomerase Vinylacetyl-CoA D-isomerase Muconolactone D-isomerase Cholestenol Delta-isomerase (EBP) Methylitaconate D-isomerase Aconitate Delta-isomerase Enoyl CoA isomerase Prostaglandin-A1 Delta-isomerase 5-carboxymethyl-2-hydroxymuconate D-isomerase Isopiperitenone D-isomerase L-dopachrome isomerase Polyenoic fatty acid isomerase

5.3.4: S-S	Protein disulfide-isomerase (PDIA3)

5.3.99: other	Prostaglandin D2 synthase/Prostaglandin-D synthase Prostaglandin E synthase Prostacyclin synthase Thromboxane-A synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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