TEGT

Transmembrane BAX inhibitor motif containing 6
Identifiers
Symbols	TMBIM6 ; BAXI1; BI-1; TEGT
External IDs	OMIM: 600748 MGI: 99682 HomoloGene: 2419 GeneCards: TMBIM6 Gene
Gene ontology Molecular function • protein binding • enzyme binding • ubiquitin protein ligase binding • endoribonuclease inhibitor activity Cellular component • nucleus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of plasma membrane • membrane • integral component of membrane • mitochondrial membrane Biological process • response to unfolded protein • spermatogenesis • lung development • negative regulation of mRNA cleavage • negative regulation of protein binding • endoplasmic reticulum calcium ion homeostasis • negative regulation of apoptotic process • negative regulation of immunoglobulin secretion • negative regulation of endoribonuclease activity • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • response to L-glutamate • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway • negative regulation of IRE1-mediated unfolded protein response • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • negative regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7009	110213
Ensembl	ENSG00000139644	ENSMUSG00000023010
UniProt	P55061	Q9D2C7
RefSeq (mRNA)	NM_001098576	NM_001171034
RefSeq (protein)	NP_001092046	NP_001164505
Location (UCSC)	Chr 12: 49.71 – 49.76 Mb	Chr 15: 99.39 – 99.41 Mb
PubMed search

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene.^[1][2][3]

References

1. Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.
2. Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.
3. "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID 10087504.
• Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics 57 (2): 201–8. doi:10.1006/geno.1999.5761. PMID 10198159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC 1868227. PMID 12875974.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer 106 (3): 648–53. doi:10.1002/cncr.21639. PMID 16353209.
• Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi:10.1074/jbc.M700053200. PMID 17526500.