TELO2

Telomere maintenance 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4PSI​
Identifiers
Symbols	TELO2 ; CLK2; TEL2
External IDs	OMIM: 611140 MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2 Gene
Gene ontology Molecular function • protein binding • protein complex binding • protein complex scaffold Cellular component • chromosome, telomeric region • intracellular • nucleus • cytoplasm • membrane • TORC1 complex • TORC2 complex Biological process • regulation of TOR signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9894	71718
Ensembl	ENSG00000100726	ENSMUSG00000024170
UniProt	Q9Y4R8	Q9DC40
RefSeq (mRNA)	NM_016111	NM_001163661
RefSeq (protein)	NP_057195	NP_001157133
Location (UCSC)	Chr 16: 1.49 – 1.51 Mb	Chr 17: 25.1 – 25.12 Mb
PubMed search

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.^[1][2][3][4]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
3. Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
4. "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".

Further reading

• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.