TESK2

Testis-specific kinase 2
Identifiers
Symbol	TESK2
External IDs	OMIM: 604746 MGI: 2385204 HomoloGene: 5188 GeneCards: TESK2 Gene
EC number	2.7.12.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • protein binding • ATP binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • protein phosphorylation • spermatogenesis • peptidyl-tyrosine phosphorylation • actin cytoskeleton organization • focal adhesion assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10420	230661
Ensembl	ENSG00000070759	ENSMUSG00000033985
UniProt	Q96S53	Q8VCT9
RefSeq (mRNA)	NM_007170	NM_146151
RefSeq (protein)	NP_009101	NP_666263
Location (UCSC)	Chr 1: 45.34 – 45.49 Mb	Chr 4: 116.72 – 116.81 Mb
PubMed search

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.^[1][2]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis.^[2]

References

1. Rosok O, Pedeutour F, Ree AH, Aasheim HC (Nov 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.
2. "Entrez Gene: TESK2 testis-specific kinase 2".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Toshima JY, Toshima J, Watanabe T, Mizuno K (2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
• Toshima J, Toshima JY, Takeuchi K, et al. (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.". J. Biol. Chem. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.