TFEC

Transcription factor EC
Identifiers
Symbols	TFEC ; TCFEC; TFE-C; TFEC-L; TFECL; bHLHe34; hTFEC-L
External IDs	OMIM: 604732 MGI: 1333760 HomoloGene: 32148 GeneCards: TFEC Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription corepressor activity • protein binding • protein dimerization activity Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • transcription from RNA polymerase II promoter • cellular response to heat • positive regulation of transcription from RNA polymerase II promoter • negative regulation of nucleic acid-templated transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22797	21426
Ensembl	ENSG00000105967	ENSMUSG00000029553
UniProt	O14948	Q9WTW4
RefSeq (mRNA)	NM_001018058	NM_031198
RefSeq (protein)	NP_001018068	NP_112475
Location (UCSC)	Chr 7: 115.94 – 116.16 Mb	Chr 6: 16.83 – 16.9 Mb
PubMed search

Transcription factor EC is a protein that in humans is encoded by the TFEC gene.^[1][2]

References

1. Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
2. "Entrez Gene: TFEC transcription factor EC".

Further reading

• Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.". Mol. Cell. Biol. 13 (8): 4505–12. PMC 360062. PMID 8336698.
• Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.". Development 125 (23): 4607–16. PMID 9806910.
• Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells.". Biochemistry 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
• Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.". J. Leukoc. Biol. 71 (2): 304–10. PMID 11818452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.