Trefoil factor 1

Trefoil factor 1

PDB rendering based on 1hi7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TFF1 ; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2
External IDs OMIM: 113710 MGI: 88135 HomoloGene: 2426 GeneCards: TFF1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7031 21784
Ensembl ENSG00000160182 ENSMUSG00000024032
UniProt P04155 Q08423
RefSeq (mRNA) NM_003225 NM_009362
RefSeq (protein) NP_003216 NP_033388
Location (UCSC) Chr 21:
42.36 – 42.37 Mb
Chr 17:
31.16 – 31.17 Mb
PubMed search

Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene[1][2] (also called pS2 gene[3]).

Function

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.[2]

In gastric carcinoma

TFF1 expression is frequently lost in gastric carcinoma, probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene. [4]


References

  1. Gött P, Beck S, Machado JC, Carneiro F, Schmitt H, Blin N (May 1997). "Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression". Eur J Hum Genet 4 (6): 308–15. PMID 9043862.
  2. 1 2 "Entrez Gene: TFF1 trefoil factor 1".
  3. Chatagnon A, Ballestar E, Esteller M, Dante R (2010). "A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene". PLoS ONE 5 (3): e9665. doi:10.1371/journal.pone.0009665. PMC 2837351. PMID 20300195.
  4. Feng G, Zhang Y, Yuan H, Bai R, Zheng J, Zhang J, Song M (Jan 2014). "DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma.". J Mol Med Rep 9 (1): 109–117. doi:10.3892/mmr.2013.1772. PMID 24190027.

Further reading


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