Thrombospondin-2

Thrombospondin 2
PDB rendering based on 1yo8.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YO8​, 2RHP​
Identifiers
Symbols	THBS2 ; TSP2
External IDs	OMIM: 188061 MGI: 98738 HomoloGene: 2438 GeneCards: THBS2 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • heparin binding Cellular component • extracellular region • basement membrane • platelet alpha granule Biological process • cell adhesion • negative regulation of angiogenesis • positive regulation of synapse assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7058	21826
Ensembl	ENSG00000186340	ENSMUSG00000023885
UniProt	P35442	Q03350
RefSeq (mRNA)	NM_003247	NM_011581
RefSeq (protein)	NP_003238	NP_035711
Location (UCSC)	Chr 6: 169.22 – 169.25 Mb	Chr 17: 14.67 – 14.69 Mb
PubMed search

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.^[1][2]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.^[2]

Interactions

THBS2 has been shown to interact with MMP2.^[3]

References

1. Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130.
2. "Entrez Gene: THBS2 thrombospondin 2".
3. Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.

Further reading

• Bornstein P, Kyriakides TR, Yang Z, Armstrong LC, Birk DE (Dec 2000). "Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis". The Journal of Investigative Dermatology. Symposium Proceedings / the Society for Investigative Dermatology, Inc. [And] European Society for Dermatological Research 5 (1): 61–6. doi:10.1046/j.1087-0024.2000.00005.x. PMID 11147677.
• O'Rourke KM, Laherty CD, Dixit VM (Dec 1992). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". The Journal of Biological Chemistry 267 (35): 24921–4. PMID 1459996.
• LaBell TL, Milewicz DJ, Disteche CM, Byers PH (Mar 1992). "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans". Genomics 12 (3): 421–9. doi:10.1016/0888-7543(92)90430-Z. PMID 1559694.
• LaBell TL, Byers PH (Jul 1993). "Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region". Genomics 17 (1): 225–9. doi:10.1006/geno.1993.1308. PMID 8406456.
• Adolph KW, Liska DJ, Bornstein P (Jul 1997). "Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2)". Gene 193 (1): 5–11. doi:10.1016/S0378-1119(97)00070-X. PMID 9249061.
• Kyriakides TR, Zhu YH, Smith LT, Bain SD, Yang Z, Lin MT, Danielson KG, Iozzo RV, LaMarca M, McKinney CE, Ginns EI, Bornstein P (Jan 1998). "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis". The Journal of Cell Biology 140 (2): 419–30. doi:10.1083/jcb.140.2.419. PMC 2132586. PMID 9442117.
• Adolph KW (May 1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochemical and Biophysical Research Communications 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
• Carron JA, Bowler WB, Wagstaff SC, Gallagher JA (Sep 1999). "Expression of members of the thrombospondin family by human skeletal tissues and cultured cells". Biochemical and Biophysical Research Communications 263 (2): 389–91. doi:10.1006/bbrc.1999.1380. PMID 10491303.
• Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.
• Hawighorst T, Velasco P, Streit M, Hong YK, Kyriakides TR, Brown LF, Bornstein P, Detmar M (Jun 2001). "Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism". The EMBO Journal 20 (11): 2631–40. doi:10.1093/emboj/20.11.2631. PMC 125494. PMID 11387198.
• Misenheimer TM, Hahr AJ, Harms AC, Annis DS, Mosher DF (Dec 2001). "Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2". The Journal of Biological Chemistry 276 (49): 45882–7. doi:10.1074/jbc.M104218200. PMID 11590138.
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S (Jun 2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". The International Journal of Biochemistry & Cell Biology 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
• Li Z, Calzada MJ, Sipes JM, Cashel JA, Krutzsch HC, Annis DS, Mosher DF, Roberts DD (Apr 2002). "Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior". The Journal of Cell Biology 157 (3): 509–19. doi:10.1083/jcb.200109098. PMC 2173289. PMID 11980922.
• Armstrong LC, Björkblom B, Hankenson KD, Siadak AW, Stiles CE, Bornstein P (Jun 2002). "Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism". Molecular Biology of the Cell 13 (6): 1893–905. doi:10.1091/mbc.E01-09-0066. PMC 117612. PMID 12058057.
• Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Miyamori I, Uchida K (Jul 2002). "Thrombospondin expression in aldosterone-producing adenomas". Hypertension Research 25 (4): 523–7. doi:10.1291/hypres.25.523. PMID 12358136.
• Boekholdt SM, Trip MD, Peters RJ, Engelen M, Boer JM, Feskens EJ, Zwinderman AH, Kastelein JJ, Reitsma PH (Dec 2002). "Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction". Arteriosclerosis, Thrombosis, and Vascular Biology 22 (12): e24–7. doi:10.1161/01.ATV.0000046235.22451.66. PMID 12482844.
• Kyriakides TR, Rojnuckarin P, Reidy MA, Hankenson KD, Papayannopoulou T, Kaushansky K, Bornstein P (May 2003). "Megakaryocytes require thrombospondin-2 for normal platelet formation and function". Blood 101 (10): 3915–23. doi:10.1182/blood.V101.10.3915. PMID 12732502.
• Kishi M, Nakamura M, Nishimine M, Ishida E, Shimada K, Kirita T, Konishi N (Jun 2003). "Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas". Cancer Science 94 (6): 530–5. doi:10.1111/j.1349-7006.2003.tb01478.x. PMID 12824879.