TIMP1

TIMP metallopeptidase inhibitor 1
PDB rendering based on 1d2b.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1D2B​, 1LQN​, 1OO9​, 1UEA​, 2J0T​, 3MA2​, 3V96​
Identifiers
Symbols	TIMP1 ; CLGI; EPA; EPO; HCI; TIMP
External IDs	OMIM: 305370 MGI: 98752 HomoloGene: 36321 GeneCards: TIMP1 Gene
Gene ontology Molecular function • protease binding • cytokine activity • protein binding • growth factor activity • metalloendopeptidase inhibitor activity • metal ion binding Cellular component • extracellular region • proteinaceous extracellular matrix • basement membrane • extracellular space • platelet alpha granule lumen • extracellular exosome Biological process • platelet degranulation • aging • blood coagulation • positive regulation of cell proliferation • response to hormone • negative regulation of endopeptidase activity • extracellular matrix disassembly • platelet activation • extracellular matrix organization • response to cytokine • negative regulation of apoptotic process • response to peptide hormone • negative regulation of metalloenzyme activity • negative regulation of membrane protein ectodomain proteolysis • cartilage development • negative regulation of trophoblast cell migration • regulation of integrin-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7076	21857
Ensembl	ENSG00000102265	ENSMUSG00000001131
UniProt	P01033	P12032
RefSeq (mRNA)	NM_003254	NM_001044384
RefSeq (protein)	NP_003245	NP_001037849
Location (UCSC)	Chr X: 47.58 – 47.59 Mb	Chr X: 20.87 – 20.87 Mb
PubMed search

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.

This protein is a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.

Other names

• Erythroid potentiating activity (EPA)
• Human collagenase inhibitor (HCI)

Regulation of TIMP expression

Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.^[1]

In adrenocortical cells the trophic hormone ACTH induces expression of TIMP-1 and the increase in TIMP expression is also associated with decreased collagenase activity.^[2]

Increased expression of TIMP1 has been found to be associated with worse prognosis of various tumors, such as laryngeal carcinoma ^[3] or melanoma.^[4]

See also

• TIMP2, TIMP3, TIMP4

References

1. "Entrez Gene: TIMP1 TIMP metallopeptidase inhibitor 1".
2. Reichenstein M, Reich R, LeHoux JG, Hanukoglu I (February 2004). "ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells". Mol. Cell. Endocrinol. 215 (1-2): 109–14. doi:10.1016/j.mce.2003.11.011. PMID 15026182.
3. Ma J (Dec 2013). "Upregulated TIMP-1 correlates with poor prognosis of laryngeal squamous cell carcinoma.". Int J Clin Exp Pathol. 15 (1): 246–54. PMC 3885479. PMID 24427345.
4. Tarhini AA (Jan 2014). "A four-marker signature of TNF-RII, TGF-α, TIMP-1 and CRP is prognostic of worse survival in high-risk surgically resected melanoma..". J Transl Med. 12. doi:10.1186/1479-5876-12-19. PMC 3909384. PMID 24457057.

Further reading

• Hornebeck W (2004). "Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival.". Pathol. Biol. 51 (10): 569–73. doi:10.1016/j.patbio.2003.09.003. PMID 14622947.
• Gardner J, Ghorpade A (2004). "Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system.". J. Neurosci. Res. 74 (6): 801–6. doi:10.1002/jnr.10835. PMID 14648584.

External links

• The MEROPS online database for peptidases and their inhibitors: I35.001