TIPIN

TIMELESS interacting protein
Identifiers
Symbols	TIPIN ; FLJ20516
External IDs	OMIM: 610716 MGI: 1921571 HomoloGene: 32373 GeneCards: TIPIN Gene
Gene ontology Molecular function • protein binding Cellular component • nuclear chromatin • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • intracellular membrane-bounded organelle Biological process • DNA replication checkpoint • mitotic nuclear division • positive regulation of cell proliferation • response to UV • intra-S DNA damage checkpoint • regulation of nuclear cell cycle DNA replication • cell cycle phase transition • replication fork protection • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54962	66131
Ensembl	ENSG00000075131	ENSMUSG00000032397
UniProt	Q9BVW5	Q91WA1
RefSeq (mRNA)	NM_001289986	NM_025372
RefSeq (protein)	NP_001276915	NP_079648
Location (UCSC)	Chr 15: 66.34 – 66.39 Mb	Chr 9: 64.28 – 64.3 Mb
PubMed search

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.^[1][2][3]

Interactions

TIPIN has been shown to interact with Replication protein A1.^[4]

References

1. Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
2. Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
3. "Entrez Gene: TIPIN TIMELESS interacting protein".
4. Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Further reading

• Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.
• Gotter AL, Suppa C, Emanuel BS (Feb 2007). "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors". Journal of Molecular Biology 366 (1): 36–52. doi:10.1016/j.jmb.2006.10.097. PMID 17141802.
• Chou DM, Elledge SJ (Nov 2006). "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function". Proceedings of the National Academy of Sciences of the United States of America 103 (48): 18143–7. doi:10.1073/pnas.0609251103. PMC 1654129. PMID 17116885.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.