Tight junction protein 2

Tight junction protein 2

PDB rendering based on 2csj.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TJP2 ; C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2
External IDs OMIM: 607709 MGI: 1341872 HomoloGene: 3541 GeneCards: TJP2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9414 21873
Ensembl ENSG00000119139 ENSMUSG00000024812
UniProt Q9UDY2 Q9Z0U1
RefSeq (mRNA) NM_001170414 NM_001198985
RefSeq (protein) NP_001163885 NP_001185914
Location (UCSC) Chr 9:
69.12 – 69.26 Mb
Chr 19:
24.09 – 24.23 Mb
PubMed search

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.[1]

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton.[supplied by OMIM][2]

Interactions

Tight junction protein 2 has been shown to interact with Tight junction protein 1,[3][4][5] Band 4.1[6] and Occludin.[3][4][7]

References

  1. Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M (November 1994). "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb". Hum Mol Genet 3 (6): 909–914. doi:10.1093/hmg/3.6.909. PMID 7951235.
  2. "Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)".
  3. 1 2 Itoh, M; Morita K; Tsukita S (February 1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. (UNITED STATES) 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. ISSN 0021-9258. PMID 10026224.
  4. 1 2 Wittchen, E S; Haskins J; Stevenson B R (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. (UNITED STATES) 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.
  5. Fanning, A S; Jameson B J; Jesaitis L A; Anderson J M (November 1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton". J. Biol. Chem. (UNITED STATES) 273 (45): 29745–29753. doi:10.1074/jbc.273.45.29745. ISSN 0021-9258. PMID 9792688.
  6. Mattagajasingh, S N; Huang S C; Hartenstein J S; Benz E J (September 2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. (UNITED STATES) 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. ISSN 0021-9258. PMID 10874042.
  7. Peng, Bi-Hung; Lee J Ching; Campbell Gerald A (December 2003). "In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis". J. Biol. Chem. (United States) 278 (49): 49644–49651. doi:10.1074/jbc.M302782200. ISSN 0021-9258. PMID 14512431.

Further reading


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