TJP3

Tight junction protein 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3KFV​
Identifiers
Symbols	TJP3 ; ZO-3; ZO3
External IDs	OMIM: 612689 MGI: 1351650 HomoloGene: 8458 GeneCards: TJP3 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • bicellular tight junction • apical plasma membrane • cell junction Biological process • regulation of G1/S transition of mitotic cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27134	27375
Ensembl	ENSG00000105289	ENSMUSG00000034917
UniProt	O95049	E9QL54
RefSeq (mRNA)	NM_001267560	NM_001282095
RefSeq (protein)	NP_001254489	NP_001269024
Location (UCSC)	Chr 19: 3.71 – 3.75 Mb	Chr 10: 81.27 – 81.29 Mb
PubMed search

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.^[1]

Interactions

TJP3 has been shown to interact with Tight junction protein 1.^[2]

References

1. "Entrez Gene: TJP3 tight junction protein 3 (zona occludens 3)".
2. Wittchen, E S; Haskins J; Stevenson B R (Dec 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. (UNITED STATES) 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.

Further reading

• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.". J. Biol. Chem. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
• Kausalya PJ, Reichert M, Hunziker W (2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells.". FEBS Lett. 505 (1): 92–6. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048.
• Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
• Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3.". J. Biol. Chem. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
• Haskins J, Gu L, Wittchen ES, et al. (1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.". J. Cell Biol. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.