TLE4

Transducin-like enhancer of split 4
PDB rendering based on 1gxr.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1gxr​, 2ce8​, 2ce9​
Identifiers
Symbols	TLE4 ; BCE-1; BCE1; E(spI); ESG; ESG4; GRG4; Grg-4
External IDs	OMIM: 605132 MGI: 104633 HomoloGene: 38259 GeneCards: TLE4 Gene
Gene ontology Molecular function • molecular_function • chromatin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcription corepressor activity • protein binding • repressing transcription factor binding Cellular component • nucleus • nucleoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • Notch signaling pathway • biological_process • Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7091	21888
Ensembl	ENSG00000106829	ENSMUSG00000024642
UniProt	Q04727	Q62441
RefSeq (mRNA)	NM_001282748	NM_001302947
RefSeq (protein)	NP_001269677	NP_001289876
Location (UCSC)	Chr 9: 79.57 – 79.73 Mb	Chr 19: 14.45 – 14.6 Mb
PubMed search

Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.^[1][2]

Interactions

TLE4 has been shown to interact with PAX5.^[3][4]

References

1. Miyasaka H, Choudhury BK, Hou EW, Li SS (October 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". Eur J Biochem 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
2. "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".
3. Eberhard, D; Jiménez G; Heavey B; Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". EMBO J. (ENGLAND) 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. ISSN 0261-4189. PMC 384353. PMID 10811620.
4. Milili, Michèle; Gauthier Laurent; Veran Julie; Mattei Marie-Geneviève; Schiff Claudine (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology (England) 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. ISSN 0019-2805. PMC 1782747. PMID 12153506.

Further reading

• Stifani S, Blaumueller CM, Redhead NJ, et al. (1993). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.". Nat. Genet. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Eberhard D, Jiménez G, Heavey B, Busslinger M (2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.". EMBO J. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.
• Milili M, Gauthier L, Veran J, et al. (2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes.". Immunology 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Heimbucher T, Murko C, Bajoghli B, et al. (2007). "Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.". Mol. Cell. Biol. 27 (1): 340–51. doi:10.1128/MCB.00811-06. PMC 1800652. PMID 17060451.