SEC62

SEC62 homolog, preprotein translocation factor
Identifiers
Symbols	SEC62 ; Dtrp1; HTP1; TLOC1; TP-1
External IDs	OMIM: 602173 MGI: 1916526 HomoloGene: 2449 GeneCards: SEC62 Gene
Gene ontology Molecular function • receptor activity • protein transporter activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • rough endoplasmic reticulum • cytosol • membrane • integral component of membrane • aggresome • intermediate filament cytoskeleton Biological process • cotranslational protein targeting to membrane • posttranslational protein targeting to membrane • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7095	69276
Ensembl	ENSG00000008952	ENSMUSG00000027706
UniProt	Q99442	Q8BU14
RefSeq (mRNA)	NM_003262	NM_027016
RefSeq (protein)	NP_003253	NP_081292
Location (UCSC)	Chr 3: 169.97 – 170 Mb	Chr 3: 30.79 – 30.82 Mb
PubMed search

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.^[1][2][3]

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.^[3]

References

1. Daimon M, Susa S, Suzuki K, Kato T, Yamatani K, Sasaki H (Feb 1997). "Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1)". Biochem Biophys Res Commun 230 (1): 100–4. doi:10.1006/bbrc.1996.5892. PMID 9020021.
2. Meyer HA, Grau H, Kraft R, Kostka S, Prehn S, Kalies KU, Hartmann E (Jun 2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J Biol Chem 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID 10799540.
3. "Entrez Gene: TLOC1 translocation protein 1".

Further reading

• Daimon M, Susa S, Kato T (2000). "Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene". IUBMB Life 48 (6): 619–24. doi:10.1080/713803565. PMID 10683767.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jung V, Kindich R, Kamradt J, et al. (2006). "Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer". Mol. Cancer Res. 4 (3): 169–76. doi:10.1158/1541-7786.MCR-05-0165. PMID 16547154.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.