TLX2

T-cell leukemia homeobox 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3A03​
Identifiers
Symbols	TLX2 ; HOX11L1; NCX
External IDs	OMIM: 604240 MGI: 1350935 HomoloGene: 7575 GeneCards: TLX2 Gene
Gene ontology Molecular function • molecular_function • sequence-specific DNA binding Cellular component • cellular_component • nucleus • cytoplasm Biological process • mesoderm formation • transcription, DNA-templated • regulation of transcription, DNA-templated • biological_process • enteric nervous system development • negative regulation of dendrite morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3196	21909
Ensembl	ENSG00000115297	ENSMUSG00000068327
UniProt	O43763	Q61663
RefSeq (mRNA)	NM_016170	NM_009392
RefSeq (protein)	NP_057254	NP_033418
Location (UCSC)	Chr 2: 74.51 – 74.52 Mb	Chr 6: 83.07 – 83.07 Mb
PubMed search

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.^[1][2]

Interactions

TLX2 has been shown to interact with YWHAH.^[3]

References

1. Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenet Cell Genet 84 (1-2): 115–7. doi:10.1159/000015234. PMID 10343123.
2. "Entrez Gene: TLX2 T-cell leukemia homeobox 2".
3. Tang, S J; Suen T C; McInnes R R; Buchwald M (Sep 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". J. Biol. Chem. (UNITED STATES) 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. ISSN 0021-9258. PMID 9738002.

Further reading

• Kaifi JT, Wagner M, Schurr PG, et al. (2007). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.". Oncol. Rep. 16 (4): 915–9. doi:10.3892/or.16.4.915. PMID 16969514.
• Borghini S, Bachetti T, Fava M, et al. (2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.". Biochem. J. 395 (2): 355–61. doi:10.1042/BJ20051386. PMC 1422762. PMID 16402914.
• Parisi MA, Lipman NS, Clarke CM, et al. (2006). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.". J. Pediatr. Surg. 40 (11): 1760–5. doi:10.1016/j.jpedsurg.2005.07.010. PMID 16291166.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Iitsuka Y, Shimizu H, Kang MM, et al. (1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells.". J. Biol. Chem. 274 (34): 24401–7. doi:10.1074/jbc.274.34.24401. PMID 10446220.
• Tang SJ, Suen TC, McInnes RR, Buchwald M (1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins.". J. Biol. Chem. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. PMID 9738002.